Lotensine Pamphlet LOTENSINE Tablets (Captopril) Angiotensin Converting Enzyme Inhibitor ( A C E I). Composition: Each tablet contains: Captopril 25 mg. Poperties: Captopril, the active principle of "LOTENSINE" is an ‘Angiotensin Converting Enzyme inhibitor, thus inhibits the conversion of Angiotisin 1” to the potent vasoconstrictor substance “Angiotensin II”. The reduction of Angiotensin II” aLso decreases aldosterone secretion, and as a result, small increases in serum potassium may occur along with sodium and fluid loss. Increased pros- taglandin E. or bradykiniri con- centrations may also play a role in the antihypertensive action of Captopril. In hyperten1ve patients Captopril reduces peripheral arterial resistance and either no change or an increase in cardiac output. Captopril’s blood pressure reduction is often maximal 60 to 90 minutes after oral administration. The duration of action Is dose - dependent and may persist for 6 • 12 hours. Reduction in ...
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