Pirafene (Chlorpheniramine)

Disclaimer: This information is for educational purposes and is not a substitute for professional medical advice. Due to its sedative effects and numerous precautions, Pirafene should be used with caution and as directed by a healthcare professional.

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Pirafene (Chlorpheniramine): A Complete Guide to the Antihistamine

Manufacturer: Memphis Co. For Pharm. & Chem. Ind., Cairo, Egypt

Category: First-Generation Antihistamine (with anticholinergic effects)

Active Ingredient:

• Chlorpheniramine Maleate

Pirafene is available in multiple forms: Tablets (4 mg), Syrup (2 mg/5 ml), and Ampoules for injection (5 mg/ml).

Summary

Pirafene is a well-established, first-generation antihistamine containing Chlorpheniramine Maleate. It is used for the symptomatic relief of a wide range of allergic reactions. It works by blocking the effects of histamine, a natural substance in the body that causes allergy symptoms like sneezing, itching, watery eyes, and runny nose. Due to its sedative properties, caution is required when using this medication.

Mechanism of Action: How Does Pirafene Work?

When the body is exposed to an allergen (like pollen, dust, or certain foods), it releases histamine. Histamine binds to its receptors on cells, causing blood vessels to dilate and leak fluid, leading to nasal congestion, mucosal edema, sneezing, and itching. Pirafene works by competitively blocking these histamine receptors. By preventing histamine from binding, Pirafene effectively antagonizes and blocks these allergic reactions and relieves the associated symptoms.

Therapeutic Indications: When to Use Pirafene

Pirafene is indicated for the symptomatic relief of allergic conditions such as:

• Allergic Rhinitis (Hay Fever)
• Urticaria (Hives)
• Allergic reactions to pollen, dust, food, or drugs
• Anaphylactoid reactions (as an adjunct therapy)

Dosage and Administration

Dosage should be determined by a physician.

• Oral (Tablets & Syrup):
  • Adults: 4 mg (1 tablet or 10 ml of syrup) every 4-6 hours.
  • Children (6-12 years): 2 mg (1/2 tablet or 5 ml of syrup) every 4-6 hours.
• Parenteral (Injection): For severe reactions, administered by a healthcare professional.
  • Dosage: 10-20 mg via SC, IM, or slow IV injection.
  • Note: The injectable form should not be administered to children under 12 years of age.

Key Warnings, Precautions, and Contraindications

• Contraindications: Strictly contraindicated in patients with a known hypersensitivity to Chlorpheniramine or other antihistamines of a similar chemical structure.
• Drowsiness: Drowsiness is a significant side effect. Patients taking Pirafene should not drive, operate heavy machinery, or engage in activities requiring mental alertness.
• Medical Conditions: Use with caution in patients with narrow-angle glaucoma, peptic ulcer, prostatic hypertrophy, urinary retention, epilepsy, hyperthyroidism, or cardiovascular disease.
• Drug Interactions: The sedative effect is increased when taken with alcohol, anxiolytics (anti-anxiety meds), hypnotics (sleeping pills), and certain antidepressants (MAOIs, tricyclics).
• Pediatric Use: In young children, Pirafene may cause paradoxical excitation instead of drowsiness. Overdosage in children can be serious, potentially leading to hallucinations, convulsions, or death.
• Pregnancy & Lactation: Should only be used during pregnancy if clearly needed and prescribed by a doctor (avoid in the third trimester). Nursing should be discontinued while taking the drug.

Frequently Asked Questions (FAQ)

What is the main difference between Pirafene and newer antihistamines?

The main difference is the side effect profile. Pirafene is a "first-generation" antihistamine, which crosses the blood-brain barrier and causes significant drowsiness. Newer "second-generation" antihistamines (like Loratadine or Cetirizine) are designed to be non-drowsy or less-drowsy.

Can I drink alcohol while taking Pirafene?

No. Alcohol will significantly increase the drowsiness and sedative effects of Pirafene, which can be dangerous.

Why is Pirafene contraindicated in some conditions like glaucoma?

Pirafene has "anticholinergic" effects, which can cause drying of mucous membranes, but can also increase pressure inside the eye (worsening glaucoma) and make urination difficult (worsening prostatic hypertrophy).

Sources

1. Chlorpheniramine Information - Drugs.com
2. Chlorpheniramine - StatPearls, NCBI
3. Official Product Leaflet for Pirafene.