Velosef (Cephradine)

Disclaimer: This information is for educational purposes and is not a substitute for professional medical advice. Velosef is a prescription-only antibiotic. Inform your doctor of any history of allergy to penicillin or other antibiotics before use.

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Velosef (Cephradine): A Complete Guide to the First-Generation Cephalosporin

Manufacturer: GlaxoSmithKline (GSK) / SmithKline Beecham

Category: First-Generation Cephalosporin Antibiotic

Active Ingredient: Cephradine

Available Forms: Velosef is available in a wide range of dosage forms:

• Oral Forms: Capsules (250 mg, 500 mg), Tablets (1 g), and Powder for Oral Suspension (125 mg/5ml, 250 mg/5ml).
• Parenteral Forms: Vials for IM/IV Injection (250 mg, 500 mg, 1 g).

Summary

Velosef (Cephradine) is a versatile, broad-spectrum, first-generation cephalosporin antibiotic. It is effective against a wide range of common bacterial infections, particularly those of the skin, respiratory tract, and urinary tract. Velosef works by killing bacteria (bactericidal action) and is available in both oral and injectable forms, allowing for flexible treatment from severe, hospital-based infections to less severe, community-treated conditions.

Mechanism of Action: How Velosef Works

Velosef's active ingredient, Cephradine, is a bactericidal antibiotic that inhibits the synthesis of the bacterial cell wall. This action is similar to penicillins. By disrupting the integrity of the cell wall, the bacterium is unable to survive, leading to its death. A key advantage of Cephradine is its activity against penicillinase-producing *Staphylococci*, which are resistant to many standard penicillins.

Therapeutic Indications: When is Velosef Used?

Velosef is indicated for the treatment of infections caused by susceptible organisms, including:

• Respiratory Tract Infections: Tonsillitis, pharyngitis, and lobar pneumonia.
• Otitis Media (Middle Ear Infection): Especially when caused by susceptible strains of *H. influenzae*.
• Skin and Soft Tissue Infections: A primary use for first-generation cephalosporins.
• Urinary Tract Infections (UTIs): Including cystitis and prostatitis.
• Bone and Joint Infections (injectable form).
• Septicemia and Endocarditis (injectable form for serious infections).
• Surgical Prophylaxis: To reduce the incidence of post-operative infections.

Dosage and Administration

Dosage is determined by the physician based on the type and severity of the infection. Velosef can be taken without regard to meals.

• Adults (Oral):
  • Most Infections: 250 mg every 6 hours or 500 mg every 12 hours.
  • UTIs: 500 mg every 12 hours.
  • Lobar Pneumonia: 500 mg every 6 hours or 1 g every 12 hours.
• Adults (Parenteral - IM/IV): The usual daily dose is 2 to 4 g daily in four equally divided doses (e.g., 500 mg to 1 g every 6 hours). The maximum dose should not exceed 8 g per day.
• Pediatrics (Oral): The usual daily dose is 25 to 50 mg/kg/day in divided doses. For otitis media, this may be increased to 75 to 100 mg/kg/day.
• Renal Impairment: The dose or dosing interval must be adjusted in patients with impaired kidney function.

Therapy should be continued for a minimum of 48-72 hours after symptoms disappear. For infections caused by Group A beta-hemolytic streptococci, a minimum of 10 days of treatment is required.

Key Contraindications, Warnings, and Precautions

• Contraindications: Strictly contraindicated in patients with a known hypersensitivity to any cephalosporin antibiotic.
• Penicillin Allergy: There is evidence of partial cross-allergenicity between penicillins and cephalosporins. Velosef should be used with caution in patients with a history of penicillin allergy.
• Pseudomembranous Colitis: As with many broad-spectrum antibiotics, diarrhea should be monitored, as it can be a sign of this serious condition.
• False-Positive Tests: Velosef can cause a false-positive reaction for glucose in the urine with certain tests (e.g., Clinitest®) but not with enzyme-based tests.
• Pregnancy and Lactation: Should be used during pregnancy only if clearly needed. It is excreted in breast milk, so caution should be exercised in nursing mothers.

Frequently Asked Questions (FAQ)

What does "first-generation" cephalosporin mean?

First-generation cephalosporins like Velosef have excellent activity against Gram-positive bacteria (like *Staph* and *Strep*) and moderate activity against some common Gram-negative bacteria. Later generations have expanded activity against more resistant Gram-negative organisms but may have less potent Gram-positive coverage.

If I am allergic to Penicillin, can I take Velosef?

You must inform your doctor. While many people with a penicillin allergy can tolerate cephalosporins, there is a small risk of a cross-reaction. Your doctor will assess the nature of your previous reaction to decide if it is safe.

How should I store the reconstituted suspension?

After mixing the powder with water, the suspension must be kept tightly closed and stored in the refrigerator (2°C - 8°C). It should be discarded after 14 days.

Sources

1. Cephradine Professional Information - Drugs.com
2. Cephalosporins - StatPearls, NCBI
3. Official Product Leaflet for Velosef.