Friday, September 13, 2013

Tusskan

Tusskan
Tusskan syrup Composition: Each 5 ml contains: 
Guaiphenesin 
Ephedrine hydrochloride 
Dextromethorphan (as hydrobromide) 
Diphenhydramine hydrochloride
11111
Indications: 
Tusskan temporarily relieves coughs due to minor throat and bronchial irritatipn as may occur with upper respirator9 tracts infections or inhaled irritants, .Vhen complicated by viscous mucus. Dxtromethorphan hydrobromide suppresses the cough control center & relieves coaghing. Guaiphenesin helps loosen mucus and thin bronchial secretions to rid the bronchial passage way of bother some mucus, drain bronchial tubes & make coughs more productive. Ephedrine decreases nasal congestion & increases nasal airway potency. Drainage of Sinus secretions is increased & obstructed Eustachian ostia may be opened, it produces little if any rebound congestion. Diphenhydrymine hydrochloride is an antihistamine with sedative properties which helps provide temporary relief of runny nose, sneezing. watery & itchy eyes. 
Contra - Indications: 
Tusskan is contraindicated in patients with hypersensitivity to any of the ingredients and in patients receiving monoamine oxidase inhibitor (MAO) therapy, includingl4 days after stopping MAOI therapy, in patients with severe hypertension, severe coronary artery disease. The drug is contraindicated in nursing mothers and pregnancy. 
Adverse Reactions: 
Adverse reactions associated with dextromethorphan hydrobromi rare, but nausea and/or other flIT disturbances, slight dizziness & drowsi sa *letimes occur. Guaiphenesin is well tolerated and has a wide margin of safe . Adverse effects associated with guaiphenesin usually result from doses arger’1han those quired with expectoration. Reported adverse reactions include ausea,vom dizziness, headache & rash. Individuals hyperactive to ephedlne may develop ephedrine-like reactions such as tachycardia, palpitation, heackche, dizzinesS or nausea. Sympathomimetic drugs have been associated with :ertain untoward reactions including: fear, anxiety, tenseness, restlessness, tremor,weak a, pallor, respiratory difficulty, disuria, insomnia hallucinations, convulsion CNS ression, arrhythmia and cardiovascular collapse with hypotension, patientS idiosyncrasy to adrenergic agents may be manifested by insomnia, dizziness, weakness, tremor or 
arrhythmias. I
Precautions: A persistent cough may be a sign of a serious condition. If cough persists for thore than a week or tends to recur or is accompanied by fever, rash, or persistent headache, patient reevaluation should be considered. 
Before prescribing any medication to suppress or modify cough, it is importantthat the underlying cause of cough is identified, that modification of cough does: not increase the risk of clinical or physiological complications and that approp’iate therapy for the primary disease is instituted. 
Patients should be warned not to take this product if they are now taking a prescription monoamine oxidase inhibitor (MAOI), including 14 days after stopping the MAOI drug. If patients are uncertain whether a prescription drug contains a MAOI. they should consult the physician before taking this product. 
Caution should be exercised if used in patients with diabetes, hypertenion, cardiovascular diseases, hyper-reactivity to epliedrine or decreased respiratory drive. 
Use in elderly (60 years & older) are more likely to have adverse reactions to sympathomimetics in this age group may cause hallucinations, convulsions, CNS depression and death. 
Do not take this product if you are taking sedatives or tranquilizers without first consulting your doctor. 
Use caution when driving a vehicle or operating machinery. 
Drug Interaction: Serious toxicity (serotonin syndrome) has been reported in patients receiving dextromethorphan & (MAOI5) concomitantly. Dextromethorphan preparations should not be used in patients receiving MAOI drugs. 
The use of dextromethorphan may result in additive CNS depressant effects when coadministrated with alcohol, antihistamines, psychotropics or other drugs which produce CNS depression. 
sympathomimetics may reduce the antihypertensive effects of methyldopa, reserpene & veratrum alkaloid. 
Beta-adrenergic blockers & MAOIs potentiate the sypathomimetic effects of ephedrine.  Dosage & Adminitration: Adults: one teaspoolful (5 ml) 3-4 times daily. 
Children: half teasponful (2.5 ml) 3-4 times daily. 
Not to be used foruthildren less than 6 years 
Packs: 
A carton box a bottle of 100 ml Syrup & an insert. 
Storage: Keep in the monsemperature (25CC ) or below. 
Keep out of reach of children.
50 mg 
7.5n 4.56mg 
5 mg
A 
Manafactnred by 
the Tenth of Ramadan for phannaceolical indostries& Diagnostic reagents “Rameda for Hikma Pharnia, SA.E, 6th of October cIty, Egypt s s