Saturday, September 7, 2013


EREC® Tablets (Slldenafil 100 mg) Composition: 
Each tablet contains: 
Sildenatil 100mg 
-Sildenatil is a phosphodiesterase inhibitor 
-Sildenahi competitively inhibts phosphodiesterane enzyme type 5. Inhibition of that isoenzyma incrnases atoms of cGMP, thn second messenger of nitric oxide and a mediator of vasodilatation in thn penis, which relaxes corpus caversosal smooth muscle xets and increases blood tow into cavemosal spaces, thia leads to increased intra cavernosal pressure which is a major factor in producing erection. Relaxation of the corpus cavernosal smooth muscles is mediated by nitric oxide and cGMR Sildenaf I at recommended doses basso effect in the absence of sexual sbmulabos. 
Erectiie dysfunction. 
1.Adxlt dosage: half tablei (So mg sildenatilj should be administered orally before sexual activity for treatment of erectile dysfunction. Erec may be taken at anytime between half to four houm before sexual activity. 
2.Doxeu range from 25mg to 100mg deily with a maximum frequency of one time daily. 
3.A dose of 25 mg should by uned is patients with hepatic impairment, severe renal failure and age over 65 yeam old. As that may lead to increase in Sildenafil serum level and so increase is both the efficacy
and incidence of adveme effects. 
1.Conxistent with its knows effects on the nitric oxide / cGMP pathway, Erec was shown to pat estate the hypotensive effects of nitrates, and its administration to patients who are using organic nitrates, either regularly and! or intermioestly in any form is contmindicated. 
2.There isa potential for cxrdiac risk of sexual activity in pehentx with preexisting cxrdiovaxcular diseases. Therefore, treatment for erect lIe dysfunction, including Erec should sot be generally used is men for whom sexual activity ix inadvisable because of their underlying cardiovascular status. 
3.Emc is contruisdicuted in patients with retinal nerve etrophy & any disturbance of vision. 
4.Hypemenxitivity to sildenatil or any component of the tablet 
5.Prolonged erection greater then 4 houm and priepism (painful erection greater than 6 houm in duration), the patient should seek immediate medical unuiutanco, if pdapinm is sot treuted immediately, penile tissue damage and permanent loss of potency could result. 
Side effects: 
1.Eody use whole: Face oedema, heedaxhe, photosensitivity reactions, shock, esthenia, chills, allergic reactions, chest pain, visual changes, blue und transient increased brightness when taking sildesuf I at doses over 200mg. 
2.Cardiovescular: engine pectoris, AV block, syncope, tactrycardia, hypotension, myocardiul inchemix, cerebral thrombosis, cardiac arrest, heart failure, flushing is reported in dose ranging up ta 100 mg daily, cardiomyopathy, abnormal ECG 
3.Hemic & lymphatic: Anemia & leucopasia. 
4.Munculoskeletal: Arthritis, arthmsis. myalgia, tendon rupture, synovitin, sildesutil was associated with mild & transient pelvic musculoskeletal pain. 
5.Nervouu system: Tremom, vertigo, depression, insomnia, abnormal dreams, utaxia, neuralgia, neumpathy, parathesia and hypartonia. 6.5km appendages: Urticariu, herpes simplex, pruritux, sweating, skin ulcer, contact dermatitis or exfoliative dermatitis. 
7.Special senses: Myddanis, conjunctivitis, eye pain, deafness, eye
hemqrrhuge. cataract, dry eye, photophobia or ear pain. 8.Digbxtive: vomiting, glosaitis, dysphagia, gushitis, gustroeriteritin, esoprugitin, stomaiitiu, dry mouth, liver function tests abnormalities, racta hemorrhage or gingivitis. 
g.urrenital: cyntitis, socturia, urinary frequency, breast enlargement urinaEy incontinence, abnormal ejaculation, genital edema or anorgusmia. 
Drug-Drug interactions: 
Sildesutil interacts with Cimetidine, erythromycin, ketoconazole, itracr,azole, uoquinuvir, dtosuvir as they increase sildenatil xemm level. 
Rifumpicin decreases sildenatil serum level. 
The &ug is xsed with caution in: 
1.Pat’entx who have suffered from myocardial ipfarction,stroke or life- threatening errtryt hmia within the last 6 months.’ 
2.Pat)ents with resting hypotension (BR v50/50) or hypertension (E.P.e1701110) 
3.Putients with cardiac failure or comnary artery disease causing unstable engine. 
4.Patjents with anatomical deformation of the panis (cavemal fibrosis, Peyronie’s disease). 
5.Pahentx with sickle xell anemia, multiple myeloma or leukemia. ti.Patests with retinitis pigmentosa. 
7.Patientx with bleeding disordem oractive peptic ulceration. 
Storebelow 30°C awayfromdirect sunlight & outof reaxh of children. 
A bo containing 1,3,25. 50 or 100 strips, each of 1,2 or4 tablets & an insert. 
Masutactured by: ADWIA Company 
10°’ of Ramadan City