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Thioctic Acid (X—LIpoIc Acid -
Composition -
Thioctic Acid (OC-Lipoic acid ) 300 mg or 600 mg ( ThIote)orte).
Pharmacokinetics
OC-Lipoic acid (ALA) can be synthesized by both animals and humans. It seems to be readily absorbed from an oral dose and is converted easily to its reduced form, dihydrolipoic acid (DHLA), in many tissues of the body. An in vitro study indicated that normal mammalian cells appear to be capable of taking up OC-lipoic actd and reck1cng it to OH LA.
The effects of both ALA and DHLA are present both intra- and extracellularly when exposed to extracellular lipoic acid, e.g. in an oral dose.
Mechanisms of Action
ThloteXis a potent antioxidant in both fat- and water-soluble mediums. Furthermore, its antioxidant activity extends to both the oxidized form and its reduced form. DHLA is capable of regenerating ascorbic acid from dehydroascorbic acid, directly regenerating vitamin C and indirectly regenerating vitamin E.
Researchers have found Thlotç)to increase intracellular glutathione and coenzyme Q10 levels.
capable of chelating certain metals. It forms stable complexes with copper, manganese and zinc. In animal studies, it has been found to protect from arsenic poisoning; and, in both in - vivo and in vitro studies, has been found to reduce cadmium-induced hepatotoxicity. In vitro, it was found to chelate mercury from renal slices.
Clinical Indications
Diabetes: Acting as a potent antioxidant, In vitro, lipoic acid was found to stimulate glucose uptake by muscle cells in a manner similar to insulin. Lipoic acid has been used extensively in Germany for the treatment of diabetic neuropathy. Lipid peroxidation is believed to play a role in the development of neuropathy. In an in vtro study, lipoic acid was found to decrease lipid peroxidation of nerve tissue. ALA was found to significantly reduce the symptoms of neuropathy in a group of 20 diabetics. Other mechanisms to explain its potential to prevent complications of diabetes include prevention of protein glycosylation, and inhibition of aldose reductase, which subsequently inhibits conversion of glucose and galactose to sorbitol. Thus, it appears that lipoic acid has the potential to prevent diabetes(at least in aminals), influence glucose control, and prevent chronic hyperglycemia-associated complications such as neuropathy.
Cataract: The enzyme, aldose reductase, plays an important role in the development of cataract in diabetes. Thiotç’®was found to inhibit aldose reductase activity in the rat lens; and
, in further animal studies, was found to inhibit cataract formation experimentally induced by buthionine sulfoxamine.
Rest Of Pamphlet
Thioctic Acid (X—LIpoIc Acid -
Composition -
Thioctic Acid (OC-Lipoic acid ) 300 mg or 600 mg ( ThIote)orte).
Pharmacokinetics
OC-Lipoic acid (ALA) can be synthesized by both animals and humans. It seems to be readily absorbed from an oral dose and is converted easily to its reduced form, dihydrolipoic acid (DHLA), in many tissues of the body. An in vitro study indicated that normal mammalian cells appear to be capable of taking up OC-lipoic actd and reck1cng it to OH LA.
The effects of both ALA and DHLA are present both intra- and extracellularly when exposed to extracellular lipoic acid, e.g. in an oral dose.
Mechanisms of Action
ThloteXis a potent antioxidant in both fat- and water-soluble mediums. Furthermore, its antioxidant activity extends to both the oxidized form and its reduced form. DHLA is capable of regenerating ascorbic acid from dehydroascorbic acid, directly regenerating vitamin C and indirectly regenerating vitamin E.
Researchers have found Thlotç)to increase intracellular glutathione and coenzyme Q10 levels.
capable of chelating certain metals. It forms stable complexes with copper, manganese and zinc. In animal studies, it has been found to protect from arsenic poisoning; and, in both in - vivo and in vitro studies, has been found to reduce cadmium-induced hepatotoxicity. In vitro, it was found to chelate mercury from renal slices.
Clinical Indications
Diabetes: Acting as a potent antioxidant, In vitro, lipoic acid was found to stimulate glucose uptake by muscle cells in a manner similar to insulin. Lipoic acid has been used extensively in Germany for the treatment of diabetic neuropathy. Lipid peroxidation is believed to play a role in the development of neuropathy. In an in vtro study, lipoic acid was found to decrease lipid peroxidation of nerve tissue. ALA was found to significantly reduce the symptoms of neuropathy in a group of 20 diabetics. Other mechanisms to explain its potential to prevent complications of diabetes include prevention of protein glycosylation, and inhibition of aldose reductase, which subsequently inhibits conversion of glucose and galactose to sorbitol. Thus, it appears that lipoic acid has the potential to prevent diabetes(at least in aminals), influence glucose control, and prevent chronic hyperglycemia-associated complications such as neuropathy.
Cataract: The enzyme, aldose reductase, plays an important role in the development of cataract in diabetes. Thiotç’®was found to inhibit aldose reductase activity in the rat lens; and
, in further animal studies, was found to inhibit cataract formation experimentally induced by buthionine sulfoxamine.
Rest Of Pamphlet
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