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| Thiotex |
Thiotex
GIaucoma:Thiotex at dosages of either 75 mg daily for two months or 150 mg daily for one month, was administered to 75 subjects with open-angle glaucoma. Thirty-one others served as controls and were given only local hypotensive therapy.The greatest improvements in both biochemical parameters of glaucoma and visual function were seen in the group receiving 150 mg lipoic acid.
Ischemia-Reperfusion Injury: After an area has been deprived of blood for a period of time, such as occurs in the brain after a stroke or in cardiac tissue after
— clot dissolution, reperfusion of the tissues causes a burst of free radical formation. Several animal studies have demonstrated the effectiveness of DHLA in the prevention of reperfusion injury.
Other possible effects.’ Other potential therapeutic uses for ALA or DHLA include: protection from radiation injury, prevention of neurological disorders by preventing oxidative damage of the central nervous system, prevention of HIV viral replication by inhibition of reverse transcriptase, protection from the effects of cigarette smoke, and treatment of heavy metal toxicity. These are interesting theoretical considerations requiring further research.
Safety, Toxicity and Side Effects
x-Lipoic acid appears to be safe in the dosages generally prescribed clinically. The LD50 was 400-500 mg/kg after an oral dosage in animals. However, lower dosages (20 mg/kg) given intraperitoneally to severely thiamin-deficient rats ere proved to be fatal. These adverse effects were prevented when thiamine was administered with the lipoic acid. There have not been sufficient studies to guarantee safety for its use in pregnancy. Allergic skin conditions are among the few reported side effects of lipoic acid administration in humans.
Dosage
Recommended therapeutic dosage of 300-600 mg/day taken orally.
How supplied
A box of 2 strips , each strip contains 10 capsules.
Keep out of reach of children.
Manufactured by
Marcyrl Pharmaceutical Industries. Egypt
Thiotex
GIaucoma:Thiotex at dosages of either 75 mg daily for two months or 150 mg daily for one month, was administered to 75 subjects with open-angle glaucoma. Thirty-one others served as controls and were given only local hypotensive therapy.The greatest improvements in both biochemical parameters of glaucoma and visual function were seen in the group receiving 150 mg lipoic acid.
Ischemia-Reperfusion Injury: After an area has been deprived of blood for a period of time, such as occurs in the brain after a stroke or in cardiac tissue after
— clot dissolution, reperfusion of the tissues causes a burst of free radical formation. Several animal studies have demonstrated the effectiveness of DHLA in the prevention of reperfusion injury.
Other possible effects.’ Other potential therapeutic uses for ALA or DHLA include: protection from radiation injury, prevention of neurological disorders by preventing oxidative damage of the central nervous system, prevention of HIV viral replication by inhibition of reverse transcriptase, protection from the effects of cigarette smoke, and treatment of heavy metal toxicity. These are interesting theoretical considerations requiring further research.
Safety, Toxicity and Side Effects
x-Lipoic acid appears to be safe in the dosages generally prescribed clinically. The LD50 was 400-500 mg/kg after an oral dosage in animals. However, lower dosages (20 mg/kg) given intraperitoneally to severely thiamin-deficient rats ere proved to be fatal. These adverse effects were prevented when thiamine was administered with the lipoic acid. There have not been sufficient studies to guarantee safety for its use in pregnancy. Allergic skin conditions are among the few reported side effects of lipoic acid administration in humans.
Dosage
Recommended therapeutic dosage of 300-600 mg/day taken orally.
How supplied
A box of 2 strips , each strip contains 10 capsules.
Keep out of reach of children.
Manufactured by
Marcyrl Pharmaceutical Industries. Egypt
Thiotex
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