ACNE-STOP System (Cream + Facial Wash)
Category
Skin care – Anti-acne product
Active Ingredients
- Oleanolic Acid
- NDGA (Nordihydroguaiaretic Acid)
- Propolis
- Osmotic Gel
Mechanism of Action
Oleanolic acid reduces sebum production and has anti-inflammatory activity. NDGA inhibits 5-lipoxygenase, reducing comedogenesis and acne inflammation. Propolis provides antibacterial and healing effects. Osmotic gel enhances delivery and helps unclog pores.
Therapeutic Indications
- Treatment of mild to moderate acne vulgaris
- Reduction of excess sebum and oily skin
- Improvement of skin texture and prevention of comedones
- Adjunct therapy with systemic or topical anti-acne agents
Pharmacokinetics
Topically applied; minimal systemic absorption. Local action on sebaceous glands and pilosebaceous units. Safe for repeated use due to low systemic bioavailability.
Dosage & Administration
- ACNE-STOP Cream: Apply thinly to affected areas twice daily.
- ACNE-STOP Facial Wash: Use to cleanse face once or twice daily before applying cream.
- Recommended duration: at least 8 weeks for best results.
Available Forms
- ACNE-STOP Cream 30 g
- ACNE-STOP Facial Wash 250 ml
- ACNE-STOP System (Cream + Wash)
Side Effects
- Mild skin irritation
- Redness or dryness, especially at start of therapy
- Rare: allergic reaction to propolis
Contraindications
- Known hypersensitivity to any component (oleanolic acid, NDGA, propolis, osmotic gel)
- Severe eczema or damaged skin areas
Precautions & Warnings
- Avoid contact with eyes and mucous membranes.
- Discontinue use if severe irritation occurs.
- Not recommended for children under 12 years without medical advice.
Drug Interactions
No major drug interactions reported. Can be used with systemic acne medications (e.g., antibiotics, isotretinoin) under supervision. Avoid simultaneous use with strong peeling agents to minimize irritation.
Use in Pregnancy & Lactation
Safety not fully established. Use with caution during pregnancy and breastfeeding; consult a physician before use.
Use in Pediatrics & Geriatrics
Pediatric: Limited safety data below 12 years of age. Geriatric: Safe with normal topical use.
Overdose
Topical overdose unlikely; may cause increased irritation or dermatitis. Ingestion requires symptomatic treatment and medical attention.
Storage
Store at room temperature below 25°C. Keep out of reach of children.
Price & Manufacturer
- ACNE-STOP Cream 30 g: Mash Premiere
- ACNE-STOP Facial Wash 250 ml: Mash Premiere
- ACNE-STOP System: Mash Premiere
Summary
ACNE-STOP is a dermatological system combining cream and facial wash with natural actives (oleanolic acid, NDGA, propolis) in an osmotic gel base. It helps reduce acne lesions, sebum production, and skin inflammation, making it a safe and effective option for acne management.
Frequently Asked Questions (FAQ)
How long does ACNE-STOP take to show results?
Visible improvement may appear within 4 weeks; optimal results after 8-12 weeks.
Can ACNE-STOP be combined with other acne treatments?
Yes, it may be combined with oral or topical treatments, but consult a dermatologist first.
Is ACNE-STOP safe for sensitive skin?
It may cause mild irritation initially. Start with once-daily use if sensitive.
Can I use makeup with ACNE-STOP?
Yes, but apply cream first, allow absorption, then use non-comedogenic makeup.
References
- Thiboutot D, et al. "Acne Pathogenesis and Treatment." J Am Acad Dermatol. 2009.
- Premiere Pharma Product Information Leaflet: ACNE-STOP System.
- PubChem Database: Oleanolic Acid, NDGA, Propolis properties.
Disclaimer
This information is provided for educational purposes only and does not replace medical advice. Consult a qualified healthcare provider before starting or changing any treatment.
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