Important Disclaimer: This summary is for educational and informational purposes only and should not, under any circumstances, replace direct consultation with a qualified physician or pharmacist. Always refer to the product's internal leaflet or consult a healthcare professional before use.
Acetasee 1% Eye Drops (Susp.) 5ml
Manufacturer
Acetasee is manufactured by Rameda (Tenth of Ramadan for Pharmaceutical Industries and Diagnostic Reagents), a well-known Egyptian pharmaceutical company.
Summary
Acetasee 1% is a sterile ophthalmic suspension containing Prednisolone Acetate, a potent corticosteroid. It is designed for topical application to the eye to treat various inflammatory and allergic conditions. By suppressing the body's inflammatory response, Acetasee effectively reduces symptoms such as swelling, redness, itching, and pain in the eye. The "suspension" form requires shaking before use to ensure the drug is evenly distributed.
Indications and Usage
Acetasee is indicated for the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, such as:
- Allergic conjunctivitis.
- Anterior uveitis (inflammation of the middle layer of the eye).
- Corneal injury from chemical, radiation, or thermal burns, or from penetration of foreign bodies.
- Post-operative inflammation following eye surgery.
- Herpes zoster keratitis (shingles affecting the eye).
Note: It should not be used for most viral diseases of the cornea and conjunctiva, especially herpes simplex keratitis (dendritic keratitis).
Characteristics
- Form: Ophthalmic Suspension (Eye Drops).
- Active Ingredient per 1 ml:
- Prednisolone Acetate: 10 mg (which is equivalent to 1%)
- Mechanism of Action: Prednisolone is a glucocorticoid that works by inhibiting the inflammatory response. It prevents the release of substances that cause inflammation, such as prostaglandins and leukotrienes, and suppresses the migration of inflammatory cells like neutrophils. This leads to a marked reduction in edema, redness, and pain.
Dosage and Administration
Important: Dosage is determined by a physician based on the severity of the condition. Do not self-prescribe.
- General Guidance: Instill one to two drops into the conjunctival sac of the affected eye(s) two to four times a day.
- Severe Conditions: During the initial 24 to 48 hours, the dosage may be increased to 2 drops every hour.
- Administration:
- Wash your hands thoroughly before use.
- Shake the bottle well before each use.
- Tilt your head back, look up, and gently pull down the lower eyelid to create a small pocket.
- Hold the dropper tip close to the eye without touching it. Squeeze the prescribed number of drops into the pocket.
- Close your eye for 1-2 minutes and press gently on the corner of your eye near the nose to prevent the liquid from draining out.
- Frequency should be gradually decreased as the inflammation subsides. Do not discontinue therapy prematurely.
Contraindications
Acetasee is contraindicated in the following conditions:
- Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis).
- Fungal diseases of the eye.
- Mycobacterial infection of the eye (e.g., ocular tuberculosis).
- Hypersensitivity to any component of the formulation.
Warnings and Precautions
- Prolonged Use: Long-term use of topical corticosteroids may result in glaucoma, damage to the optic nerve, defects in visual acuity, and cataract formation. Intraocular pressure (IOP) should be monitored if used for 10 days or longer.
- Secondary Infection: Prolonged use may suppress the host immune response and thus increase the hazard of secondary ocular infections. Fungal infections should be suspected in any persistent corneal ulceration where a steroid has been used.
- Corneal Thinning: In diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids.
- Contact Lenses: The preservative in Acetasee (benzalkonium chloride) may be absorbed by soft contact lenses. Remove contact lenses before application and wait at least 15 minutes before reinserting them.
- Do not stop treatment abruptly without consulting your doctor, as this can cause a rebound of inflammation.
Side Effects
Adverse reactions can occur with ophthalmic steroid use. These include:
- Elevation of intraocular pressure (IOP) with possible development of glaucoma.
- Optic nerve damage.
- Posterior subcapsular cataract formation.
- Delayed wound healing.
- Stinging, burning, or temporary blurring of vision upon instillation.
- Risk of secondary ocular infection (fungal or viral).
Patient Counseling & Storage
- Shake the bottle vigorously before every single use.
- To prevent contamination, do not touch the dropper tip to any surface, including your eye or hands.
- If you are using other eye drops, wait at least 5-10 minutes between applications.
- Do not wear contact lenses during treatment unless approved by your doctor.
- Store the bottle upright at a temperature below 30°C. Do not freeze.
- Discard the bottle 28 days after opening to prevent contamination.
- Keep out of the reach of children.
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