.**Important Disclaimer:** This summary is for educational and informational purposes only and should not, under any circumstances, replace direct consultation with a qualified physician or pharmacist. Always refer to the product's internal leaflet or consult a healthcare professional before use.
**Drug Name:** Accelafen 30 F.C. Tab.
**Manufacturer:**
Based on available information, Accelafen 30 F.C. Tab. is manufactured by **True Pharma** in some regions, particularly in Egypt.
**Main Commentary Body:**
Accelafen 30 F.C. Tab. is a film-coated dietary supplement containing a combination of B vitamins: Vitamin B1 (Thiamine), Vitamin B6 (Pyridoxine), and Vitamin B12 (Cobalamin). This combination is primarily used to support the health of the nervous system, aid in energy metabolism, and contribute to overall well-being.
* **Indications and Usage:**
Accelafen 30 F.C. Tab. is indicated as a dietary supplement to:
* Support the normal functioning of the nervous system.
* Help prevent and treat deficiencies of Vitamin B1, B6, and B12.
* Aid in energy production and metabolism.
* Contribute to the formation of red blood cells (Vitamin B12).
* Support nerve regeneration and reduce symptoms associated with nerve damage (e.g., neuropathy, tingling, numbness) that may be linked to B vitamin deficiencies.
* **Characteristics:**
This supplement combines three essential B vitamins, each playing a crucial role in the body:
* **Vitamin B1 (Thiamine):** Essential for carbohydrate metabolism and plays a vital role in nerve function, muscle contraction, and heart function.
* **Vitamin B6 (Pyridoxine):** Involved in over 100 enzyme reactions, primarily in protein metabolism. It is crucial for brain development and function, and for the production of neurotransmitters.
* **Vitamin B12 (Cobalamin):** Necessary for red blood cell formation, neurological function, and DNA synthesis. It is particularly important for nerve health and the formation of myelin, the protective sheath around nerves.
* **Dosage and Administration:**
Accelafen 30 F.C. Tab. is for oral administration. The tablets should be swallowed whole with water.
* **Adults:** The typical recommended dose is one tablet daily, or as directed by a healthcare professional.
* It can be taken with or without food.
* Do not exceed the recommended daily dose unless specifically advised by a physician.
* **Contraindications:**
Accelafen 30 F.C. Tab. should generally not be used in individuals with:
* Known hypersensitivity or allergy to any of the active ingredients (Vitamin B1, B6, B12) or any of the excipients.
* Leber's disease (hereditary optic nerve atrophy), as Vitamin B12 may exacerbate the condition.
* **Warnings and Precautions:**
* **Masking B12 Deficiency:** High doses of Vitamin B6 can sometimes mask the symptoms of pernicious anemia (a type of Vitamin B12 deficiency), potentially leading to irreversible neurological damage if the underlying B12 deficiency is not diagnosed and treated.
* **Neuropathy (Vitamin B6):** Prolonged use of very high doses of Vitamin B6 (pyridoxine) can lead to peripheral neuropathy, characterized by numbness and tingling in the extremities. Adhere strictly to recommended doses.
* **Pregnancy and Breastfeeding:** While B vitamins are essential during pregnancy and breastfeeding, consult a healthcare professional before taking any supplements to ensure appropriate dosage and safety.
* **Underlying Conditions:** Individuals with specific medical conditions (e.g., kidney disease, liver disease) should consult their doctor before taking B vitamin supplements.
* **Nutrient Absorption and Metabolism:**
* **Absorption:** B vitamins are water-soluble, meaning they are generally well-absorbed from the gastrointestinal tract. Vitamin B12 absorption is complex and requires intrinsic factor, a protein produced in the stomach.
* **Metabolism:** Once absorbed, B vitamins are converted into their active coenzyme forms, which then participate in various metabolic pathways throughout the body, including energy production, amino acid metabolism, and nucleic acid synthesis.
* **Excretion:** Since they are water-soluble, excess B vitamins (that are not stored or used by the body) are primarily excreted in the urine. This means regular intake is necessary to maintain adequate levels.
* **Side Effects:**
B vitamin supplements are generally well-tolerated. However, some individuals may experience mild side effects, especially with higher doses:
* **Common:**
* Mild gastrointestinal upset (e.g., nausea, stomach discomfort, diarrhea).
* Unusual urine odor or bright yellow urine (due to riboflavin, often present in B-complex supplements, though not explicitly listed for Accelafen, it's a common B vitamin effect).
* **Less Common/Rare (often associated with very high doses or prolonged use):**
* Peripheral neuropathy (with very high doses of Vitamin B6).
* Allergic reactions (e.g., rash, itching, swelling) in sensitive individuals.
* **Drug Interactions:**
While B vitamins generally have few significant drug interactions at recommended doses, some medications can affect B vitamin levels or interact with them:
* **Certain Antibiotics (e.g., Isoniazid):** Can interfere with Vitamin B6 metabolism.
* **Levodopa:** High doses of Vitamin B6 can reduce the effectiveness of Levodopa (used for Parkinson's disease), though this interaction is less common with newer formulations of Levodopa that include a decarboxylase inhibitor.
* **Anticonvulsants:** Some anti-seizure medications can affect B vitamin levels.
* **Diuretics:** Some diuretics can increase the excretion of B vitamins.
* **Metformin:** Can reduce Vitamin B12 absorption.
* **Patient Counseling:**
* Take Accelafen 30 F.C. Tab. as directed by your healthcare professional or as indicated on the packaging.
* Do not exceed the recommended dose.
* If you experience any unusual or severe side effects, discontinue use and consult your doctor.
* Inform your doctor or pharmacist about all other medications, supplements, and herbal remedies you are taking.
* Store the tablets in a cool, dry place, away from direct sunlight and moisture, and out of reach of children.
* Remember that supplements are not a substitute for a balanced diet.
**Sources:**
1. Al-Abdellatif Eltarshouby Pharmacy - Accelafen 30 Film Coated Tablets: [https://bit.ly/accelafen-b12](https://vertexaisearch.cloud.google.com/grounding-api-redirect/AUZIYQG9eDb_k2vmzl7C3-ZpTWBGLR-n73hG53i-t3L2WSBQbvCGC3Y9H4p_CueUDmL9V7O7Nzgdzfs3-_PWgSCvDBtB2GUvOvdN1T8V2k_uUKUkl7WC7Rxy3rzCkuoanJtfdef8kzXv2s6qMk02rqN8ONpuo9RN1m5KSXPFZAG2XKh7iv_QuYpjq1qaSiU8gC7AQMT44qo)
2. دليل دواء مصر - Accelafen 30 f.c.tabs.: [https://bit.ly/accelafen-egypt](https://vertexaisearch.cloud.google.com/grounding-api-redirect/AUZIYQEvqsUiAAzyBrpL8XgahkyJxX3oE4_mQaAAw1qceRt2qRKFpFMGLvhlWCLT7iWMcc8Ns9Cs362bVV6DDdEwWrAQNqgfjA_puAbNuTC8NsIbN8lX73RCahFg5SBBab0WM0I)
3. MedlinePlus - B Vitamins: [https://bit.ly/medlineplus-b-vitamins](https://medlineplus.gov/bvitamins.html)
4. Mayo Clinic - Vitamin B6: [https://bit.ly/mayoclinic-b6](https://www.mayoclinic.org/drugs-supplements/vitamin-b6/side-effects/drg-20066517)
5. National Institutes of Health (NIH) - Vitamin B12: [https://bit.ly/nih-b12](https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/)
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