**Important Disclaimer:** This summary is for educational and informational purposes only and should not, under any circumstances, replace direct consultation with a qualified physician or pharmacist. Always refer to the product's internal leaflet or consult a healthcare professional before use.
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**Acanthaprop Eye Drops**
**Manufacturer:** Orchidia Pharmaceutical Industries
Acanthaprop Eye Drops are an ophthalmic solution primarily used for their anti-infective properties. The active ingredient, Propamidine Isethionate, is an aromatic diamidine disinfectant effective against certain microorganisms. This medication is typically prescribed for the treatment and prevention of minor eye and eyelid infections.
**Indications and Usage**
Acanthaprop Eye Drops are indicated for the topical treatment of minor eye infections, such as conjunctivitis and blepharitis, caused by susceptible organisms. Its active ingredient, Propamidine Isethionate, is known to be active against Gram-positive non-spore forming organisms, and has also been historically used in the management of certain parasitic eye infections like Acanthamoeba keratitis, though for the latter, it is often part of a multi-drug regimen and specific protocols apply.
**Characteristics**
Propamidine Isethionate, the active component of Acanthaprop, belongs to the diamidine class of antiseptics. It exerts its antimicrobial action by interfering with the metabolic processes of microorganisms. It is particularly noted for its activity against Gram-positive bacteria and some fungi. While its primary use is for minor bacterial and fungal infections of the eye and eyelid, its historical association with Acanthamoeba keratitis highlights its broader spectrum of activity against certain protozoa. The eye drop formulation allows for direct topical application to the affected area, providing localized treatment.
**Dosage and Administration**
* **Form:** Ophthalmic solution (eye drops).
* **Recommended Use:** One or two drops applied to the affected eye(s).
* **Frequency:** Up to four times daily. The exact frequency and duration of treatment should be determined by a healthcare professional based on the severity and type of infection. Medical advice should be obtained if there is no significant improvement after two days.
* **Administration:** For ophthalmic use only. Patients should wash their hands before use, avoid touching the dropper tip to the eye or any other surface to prevent contamination, and close the eye gently after instillation.
**Contraindications**
Acanthaprop Eye Drops are contraindicated in individuals with known hypersensitivity or allergy to Propamidine Isethionate or any other component of the formulation. It should not be used for severe or deep-seated eye infections without specific medical advice, as it may not be sufficient as a sole treatment.
**Warnings and Precautions**
* **Hypersensitivity:** Discontinue use immediately if signs of allergic reaction or irritation occur.
* **Contact Lenses:** Patients should remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them, as the preservative in the drops may be absorbed by soft contact lenses.
* **Vision:** Temporary blurred vision may occur after instillation. Patients should be advised not to drive or operate machinery until their vision clears.
* **Duration of Use:** Prolonged use of topical antimicrobials may lead to the overgrowth of non-susceptible organisms, including fungi. If the infection worsens or does not improve within a few days, re-evaluation by a healthcare professional is necessary.
* **Systemic Absorption:** While systemic absorption from topical ophthalmic application is generally minimal, caution should be exercised in patients with severe renal or hepatic impairment.
* **Keep out of reach of children.**
**Pharmacokinetics**
Propamidine Isethionate is applied topically to the eye. Systemic absorption following ophthalmic administration is generally very low, minimizing systemic side effects. The drug primarily acts locally on the surface of the eye and eyelid. Its mechanism involves disrupting the cell membrane of susceptible microorganisms. Metabolism and excretion pathways for topically applied ophthalmic diamidines are not extensively detailed for systemic routes due to minimal absorption, but local degradation and elimination through tear film turnover are expected.
**Side Effects**
* **Common (generally mild and transient):**
* Transient stinging or burning sensation upon instillation.
* Eye irritation or discomfort.
* Blurred vision (temporary).
* Eye redness (hyperaemia).
* **Less Common/Serious (often associated with hypersensitivity or prolonged use):**
* Allergic reactions (e.g., rash, itching, swelling of the eyelids).
* Corneal toxicity or damage with prolonged or excessive use, though rare with standard concentrations.
* Superinfection with non-susceptible organisms.
**Drug Interactions**
Significant drug interactions with topically applied Propamidine Isethionate are generally not well-documented due to minimal systemic absorption. However, as with any ophthalmic preparation, if other eye drops or ointments are being used concurrently, it is advisable to administer them at least 5-10 minutes apart to prevent dilution or washout of the medication. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are using.
**Patient Counseling**
* **Proper Administration:** Instruct patients on the correct technique for instilling eye drops to ensure efficacy and prevent contamination.
* **Contact Lenses:** Remind patients to remove contact lenses before use and wait before reinserting them.
* **Vision:** Advise patients about the possibility of temporary blurred vision and to avoid activities requiring clear vision until it resolves.
* **Duration of Treatment:** Emphasize the importance of completing the full course of treatment as prescribed, even if symptoms improve, to prevent recurrence or resistance. Advise to seek medical attention if symptoms persist or worsen.
* **Storage:** Counsel on proper storage, typically at room temperature, away from light and moisture, and to keep the bottle tightly closed when not in use. Discard any remaining solution after the recommended period (usually 28 days after opening).
* **Contamination:** Warn against touching the dropper tip to any surface to maintain sterility.
* **Consultation:** Strongly advise consulting a healthcare professional for any concerns, especially if symptoms do not improve, worsen, or if new symptoms appear.
* **Keep out of reach of children.**
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**Sources:**
* [https://bit.ly/OrchidiaAcanthaprop](https://orchidiapharma.com/en/Products/Ophthalmic_Products/anti-infective-eye-drops/Acanthaprop_)
* [https://bit.ly/RoshetaAcanthaprop](https://www.rosheta.com/en/13916/acanthaprop)
* [https://bit.ly/LotusAcanthaprop](https://lotusonline.com/product/acanthaprop-eye-drop-1
0ml/)
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