Abilia tablets

 Summary

Abilia is the trade name for aripiprazole tablets marketed by Chemipharm in Egypt, available in 15 mg and 20 mg film‑coated strengths for oral administration. These atypical antipsychotic tablets act as dopamine‑serotonin stabilizers and are indicated for schizophrenia, bipolar I disorder (acute manic and mixed episodes and maintenance), adjunctive treatment of major depressive disorder, irritability associated with autism spectrum disorder, and Tourette’s disorder. Typical adult dosing ranges from 10 mg to 30 mg once daily, taken without regard to meals. Common adverse effects include restlessness, insomnia, nausea, and constipation; serious risks encompass neuroleptic malignant syndrome, tardive dyskinesia, and impulse‑control issues. Store at room temperature (20–25 °C) away from moisture and light. A 30‑tablet pack of Abilia 15 mg retails for approximately EGP 105 in Egypt. 

Formulation & Composition

Strengths: Available as film‑coated tablets containing 15 mg or 20 mg of aripiprazole USP per tablet .

Excipients: Enteric‑coating polymers and common tablet excipients (e.g., acacia, calcium carbonate, polyethylene glycol) to ensure gastric protection and controlled release .

Mechanism of Action

Aripiprazole is an atypical antipsychotic that acts as a partial agonist at dopamine D₂ and serotonin 5‑HT₁A receptors and an antagonist at 5‑HT₂A receptors, thereby stabilizing neurotransmitter activity in key brain pathways implicated in psychosis and mood disorders .

Indications & Usage

Schizophrenia: Treatment of acute and maintenance phases in adults and adolescents aged ≥ 13 years .

Bipolar I Disorder: Acute manic or mixed episodes and maintenance monotherapy in adults and pediatric patients (10–17 years) .

Major Depressive Disorder (Adjunctive): Used with antidepressants in adults with inadequate response .

Irritability in Autism Spectrum Disorder: Pediatric patients 6–17 years .

Tourette’s Disorder: Management of tic severity in adults and children .

Dosage & Administration

Adults: Initiate at 10–15 mg once daily, orally, without regard to meals; effective dose range is 10–30 mg/day, not exceeding 30 mg/day .

Elderly (> 65 years): Start at 5 mg once daily and titrate cautiously, monitoring for orthostatic hypotension and falls .

Pediatrics: Schizophrenia in adolescents 13–17 years and bipolar mania in 10–17 years follow adult dosing; autism irritability in 6–17 years starts at 2 mg/day and titrates to 5–10 mg/day based on response .

Administration: Swallow tablets whole; do not chew, cut, or crush .

Adverse Effects & Precautions

Common: Akathisia/restlessness, insomnia, nausea, vomiting, constipation, dizziness, weight gain, and headache .

Serious: Neuroleptic malignant syndrome, tardive dyskinesia, impulse‑control disturbances (e.g., pathological gambling), orthostatic hypotension, and metabolic changes .

Boxed Warnings: Increased mortality in elderly patients with dementia‑related psychosis; monitor for suicidal thoughts in younger patients .

Contraindications: Known hypersensitivity to aripiprazole or formulation components .

Storage & Handling

Store film‑coated tablets at controlled room temperature, 20–25 °C (68–77 °F; excursions permitted between 15–30 °C), in a dry place away from light and moisture. Keep out of reach of children .

Availability & Pricing in Egypt

Pack Size: 30 film‑coated tablets per box.

Price: Approximately EGP 105 for a box of Abilia 15 mg × 30 tabs at Delmar & Attalla pharmacies .

Other Outlets: Widely available through community pharmacies (e.g., Sally Pha

rmacies, Wael Samir Pharma) an e‑commerce platforms.

---