Skip to main content

Nanazoxid

Nanazoxid 


Nanazoxid 
Nitazoxanide 500mg 
Intestinal Antiprotozoal Film coated tablets 
Company Name: Pharmed Healthcare for Utopia Pharmaceuticals. Composition: Each film coated tablet contains: Active Ingredients: Nitazoxanide 500mg. Inactive Ingredients: Povidone k 30, Microcristalline cellulose (Avicel PH 101),Croscarmellose sodium,Sodium starch glycolate,Colloidal silicon dioxide,Talc , Magnesium stearate ,Hydroxypropyl methylcellulose E15,PEG 6000,Titanium dioxide, Tween 80, Yellow ferric oxide. Description: Nanazoxid 500mg tablets contains the active ingredient nitazoxanide; a synthetic antiprotozoal agent for oral administration. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl) benzamide. The structural formula is: 
Clinical Pharmacology: Absorption: Following oral administration of Nanazoxid 500mg tablets, maximum plasma concentrations of the active metabolites tizoxanide and tizoxanide glucuronide are observed within 1-4 hours. The parent nitazoxanide is not detected in plasma. When Nanazoxid 500mg tablet was administered with food, the AUC, of tizoxanide and tizoxanide glucuronide increased almost two-folds and the Cmax increased by almost 50%. Distribution: In plasma, more than 99% of tizoxanide is bound to proteins. Metabolism: Nitazoxanide is rapidly hydrolyzed to an active metabolite, tizoxanide (desacetyl-nitazoxanide). Tizoxanide then undergoes conjugation, primarily by glucuronidation. Elimination: Tizoxanide is excreted in the urine, bile and feces, and tizoxanide glucuronide is excreted in urine and bile. Approximately two-thirds of the oral dose of nitazoxanide is excreted in the feces and one-third in the urine. Mechanism of Action: The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Indications and Usage: Nanazoxid 500mg tablets is indicated for the treatment of diarrhea caused by giardia lamblia or cryptosporidium parvum. Dosage and Administration: One tablet every 12 hours with food for three days. Overdosage: Information on nitazoxanide overdosage is not available. Contraindications: Nanazoxid 500gm tablets is contraindicated in patients with a prior hypersensitivity to nitazoxanide or any other ingredient in the formulation. Adverse Reactions: The most frequent adverse events reported were: Abdominal pain, diarrhea, vomiting and headache. Drug Interactions: Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g. Warfarin.) Pregnancy and Lactation: No adequate and well-controlled studies are available in pregnant women. It is not known whether nitazoxanide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when nitazoxanide is administered to a nursing women. Precautions: Nitazoxanide must be administered with caution to patients with hepatic and bilary diseases, to patients with renal diseases, and to patients with combined renal and hepatic disease. Package: Carton box containing 1 or 3 PVDC/AL Strips; each strip 6 film coated tablets with an insert leaflet.
Storage: - Keep out of reach of children. __ _ - Keep at a temperature not exceeding 30°C in a dry place. Information for Patients: Nanazoxid 500mg tablets should be taken with food. Produced by Pharmed Healthcare for Utopia Pharmaceuticals. 



Comments

Popular posts from this blog

SPASMO - DIGESTIN

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication. Spasmo-Digestin: A Comprehensive Guide to the Digestive Aid Manufacturer: Pharco Pharmaceuticals (Alexandria) Category: Digestive, Antispasmodic, and Antiflatulent Active Ingredients per Enteric-Coated Tablet: Digestive Enzymes: Papain (100mg), Sanzyme 3500 (36mg) Choleretic (Bile Stimulant): Sodium Dehydrocholate (10mg) Antispasmodic (Anti-cramping): Dicyclomine Hydrochloride (5mg) Antiflatulent (Anti-gas): Simethicone (30mg) Summary Spasmo-Digestin is a multi-action medication designed to provide comprehensive relief from a variety of digestive issues. It combines five active ingredients that work together to improve digestion, relieve painful spasms and cramps, stimulate bile flow, and reduce gas and bloating. Its unique formula makes it a popular choice ...

FLUMOX (Amoxicillin & Flucloxacillin)

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication, especially antibiotics. Complete the full course of treatment as prescribed. FLUMOX (Amoxicillin & Flucloxacillin): A Comprehensive Guide Manufacturer: EIPICO (Egyptian International Pharmaceutical Industries Co.) Category: Broad-Spectrum Antibiotic (Penicillin Combination) Active Ingredients: A combination of two penicillins: Amoxicillin (as trihydrate or sodium salt) Flucloxacillin (as monohydrate or sodium salt) Summary FLUMOX is a powerful combination antibiotic that contains two active ingredients from the penicillin family: Amoxicillin and Flucloxacillin. This dual-action formula provides a very broad spectrum of activity, making it effective against a wide range of bacterial infections. It is designed to kill bacteria that are both sensitive to standard ...

EPIMAG Effervescent Powder

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication. EPIMAG Effervescent Powder (فوار إبيماج) Manufacturer: EIPICO (Egyptian International Pharmaceutical Industries Co.) Category: Laxative & Urinary Alkalinizer Active Ingredient per 5g Sachet: Magnesium Citrate 2.125 g Summary EPIMAG is a widely used effervescent powder containing Magnesium Citrate. It serves two primary purposes: first, as an effective osmotic laxative for relieving constipation, and second, as a urinary alkalinizer used to prevent the recurrence of certain types of kidney stones (calcium oxalate stones). Its dual action makes it a versatile product for both digestive and renal health under medical supervision. Mechanism of Action Epimag's effectiveness comes from two distinct actions of its components: As a Laxative (Osmotic Action): Magne...