Skip to main content

DICYNONE

DICYNONE 



****** Result for Image/Page 1 ******
DICYNONE AMPOULES
Antihemorrhagic
Composition
DICYNONE
Each 2 m; arnpoule contains: diethylammonium I .4 dihydroxybenzenesuifonate (INN, etamsylate) 250 mg,
antiox. (E 223) 08 mg.
Each tablet contains: diethylammonium I ,4 dihydroxybenzenesulfonate (INN, etamsylate) 250 mg.
DICYNONE 500
Each tablet contains: diethylammonium I dihydroxybenzenesulfonate (INN, etamsylate) 500 mg.
antiox. (E 221).
Properties / Mode of action
Etamsy!3te is a synthetic antihernorrhagjc and angioprotective drug acting on the first step of hemostasis
(endothelium - platelet interaction). BV improving platelet adhesiveness and restonng capillary resistance, it
reduces (he bleedinq time and blood fosses. Etamsylate has no vasoconstrictor action , it does not influence
tibrinotysis nor modify the plasma coagulation factors.
Pharmacokinetics
After i.v. administration of 500 mg etamsylate, the maximum plasma level, i.e. 50 pg / ml, is reached at
10 minutes. The plasma half-life is around 1 ,9 h. About 85% oi the administered dose are excreted in the first
24 h -urine.
When given po . etamsylate is resorbed through the gastrointestinal tract. After oral administration of
500 mg etarnsvtate, maximum plasma level, i.e. 15 ug/rnl, is reached at 4 h. The plasma half-life IS around
3,7 h. About 720/0 of the administered dose are excreted in the first 24 h-urine; the molecule is excreted
unchanged.
Etamsylate crosses the placentai barrier. Materna! and cord blood contains similar concentrations of
etamsyiate.
Indications
In surgery: Prevention and treatment of per- or postsurgical oozing in all delicate operations and in those
affecting highly vascularized tissues: E.N.T, gynecology, obstetrics, urology, odontostomatology, ophthal-
mology, plastic and reconstructive surgery.
In intemal medicine: Prevention and treatment of capillary hemorrhages of whatever origin or localization;
hematuria, hematemesis, melena, metrorrhagia, primary or IUD-related menorrhagia , epistaxis, gingivorr-
hagia.
in pediatrics: Prevention of periventricular hemorrhages in premature babies.
DCYNONE
Adults:
Presurgical: 1-2 ampoules i.v. or i.m. 1 hour before surgery.
Persurgical: 1-2 ampoules i.v. Repeat the dosage if necessary.
Postsurgtcal: 1-2 ampoules (1-2 tablets). Repeat every 4-6 hours as long as the bleeding risk persists.
Emergency cases, according to the severity of the case:l -2 ampoules i.v. or i.m. Repeat every 4-6 hours as
long as the risk of bleeding persists.
Local treatment: soak a swab with the content of an ampoule and apply to hemorrhagic area, or in the tooth
socket after dental extraction. The application may be repeated when necessary; it may be associated with
oral or parenterai administration.
Children: halt the adult dose.
Pediatrics: 10 mg per kg body weight (0.1 ml-12.5 mg) injected intramuscularly wtthin 2 hours atter birth
then every 6 hours for 4 days.
DICYNONE 500
Adults:
Postsurgjcal: I tablet, repeat every 4-6 hours as long as the bleeding risk persists,
Internal medicine generally, 2-3 tablets daily; the duration of treatment depends on the results.
Gynecology, in meno-metrorrhagia: from the fifth day before the expected onset of the menstrua' period
3 tablets da.ly for 10 days.
Children: half the adult dose.
umitations for use - As for most drugs, Dicynone!Dicynone 500 Should not be taken during the first
trimester of pregnancy.
Adverse effects - Etamsyiate does not induce serological or allergic side-effects.
Interactidt* - Dicynone/Dicynone 500 may be given In association with any other drug (for example anti-
coagulants). When a perfusion with dextran is necessary. Dicynone has to be administered first.
Stability - Protect the ampoules from light. Discard Dicynone ampoules if the solution is coloured.
Dtcynone/Dlcynone 500 may be administered until the expiration date indicated on the package (EXP).
Presentations
DICYNONE
Ampoules (250 mg/2 ml): 3 , 100
0M 0M Laboratories Ltd, Meyrin-Geneva (Switzerland)

Comments

Popular posts from this blog

SPASMO - DIGESTIN

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication. Spasmo-Digestin: A Comprehensive Guide to the Digestive Aid Manufacturer: Pharco Pharmaceuticals (Alexandria) Category: Digestive, Antispasmodic, and Antiflatulent Active Ingredients per Enteric-Coated Tablet: Digestive Enzymes: Papain (100mg), Sanzyme 3500 (36mg) Choleretic (Bile Stimulant): Sodium Dehydrocholate (10mg) Antispasmodic (Anti-cramping): Dicyclomine Hydrochloride (5mg) Antiflatulent (Anti-gas): Simethicone (30mg) Summary Spasmo-Digestin is a multi-action medication designed to provide comprehensive relief from a variety of digestive issues. It combines five active ingredients that work together to improve digestion, relieve painful spasms and cramps, stimulate bile flow, and reduce gas and bloating. Its unique formula makes it a popular choice ...

FLUMOX (Amoxicillin & Flucloxacillin)

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication, especially antibiotics. Complete the full course of treatment as prescribed. FLUMOX (Amoxicillin & Flucloxacillin): A Comprehensive Guide Manufacturer: EIPICO (Egyptian International Pharmaceutical Industries Co.) Category: Broad-Spectrum Antibiotic (Penicillin Combination) Active Ingredients: A combination of two penicillins: Amoxicillin (as trihydrate or sodium salt) Flucloxacillin (as monohydrate or sodium salt) Summary FLUMOX is a powerful combination antibiotic that contains two active ingredients from the penicillin family: Amoxicillin and Flucloxacillin. This dual-action formula provides a very broad spectrum of activity, making it effective against a wide range of bacterial infections. It is designed to kill bacteria that are both sensitive to standard ...

EPIMAG Effervescent Powder

Important Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before using any medication. EPIMAG Effervescent Powder  Manufacturer: EIPICO (Egyptian International Pharmaceutical Industries Co.) Category: Laxative & Urinary Alkalinizer Active Ingredient per 5g Sachet: Magnesium Citrate 2.125 g Summary EPIMAG is a widely used effervescent powder containing Magnesium Citrate. It serves two primary purposes: first, as an effective osmotic laxative for relieving constipation, and second, as a urinary alkalinizer used to prevent the recurrence of certain types of kidney stones (calcium oxalate stones). Its dual action makes it a versatile product for both digestive and renal health under medical supervision. Mechanism of Action Epimag's effectiveness comes from two distinct actions of its components: As a Laxative (Osmotic Action): Magnesium Citrate ...