Tuesday, September 3, 2013


Paracetamol Tablets, Syrup and Suppositories. 
I Antipyretic. 
Paracetamol is composed of paracetamol (acetaminophen). 
Paracotamol tablets: Each tablet contains 500 mg. 
Paracetamol Syrup Each teaspoonful (5m1) contains 120 mg. 
Paracetamol Pediatric Suppositories: Each Contains 125mg 
Paracetemol is the chief metabolite of anilline derivatives (phenacetin & acetanitide) probably accounts for their analgesic effect 
Paracetamol exerts its analgesic action by raising the threshold of response to pain stimuli by interfering with thir relay from the thalamus to the cortex, other forms of sensations however remain completely unaffected. Like salicylates Paramol has antipyretic action, causes depletion of ascorbic acid from the adrenal cortex and reduces inflammatory changes but has no anti-rheumatic effect, 
Paracetamol is similar in itS analgesic & antipyretic effect to acetyl - salicytic acid but its free from the gastric irritant side effect induced by the later. 
Indications and usage: 1- Pain of somatic origin, e.g.: headache, toothache, pain arising from the muscuto- Skeletal system, etc. And as an analgesic in rheumatic diseases. 
2- Influenza, common cold and other febrite conditions. 
3- Dysmenorrhea. 
4-As a suitable allemative to patients sensitive to ecetyl- salicylic acid. 
5-When an analgesic is required to patients receiving anticoagulants. Paracetamol is the drug of choice, as the risk of potentiation of the antbcoagulants effect is minimal. 
Side effects: in therapeudc dose Paracetamol has no deleterious effect either on circulation or respiration nor does it impair hepahc or renal function , although haematological reactions and skin eruptions have been reported. Overdose: Over dosage may produce symptoms such as vomiting , gastrointestinal bleeding, cerebral edema, hypo or hyperglycemia, Liver damage and renal tubular necrosis may also occur due to over dosage. Dosage and administration: ADULTS :1/2 - 1 tablet every 4 - 6/hours as necessary (maximum 2.4 gm in 24 hours). 
CHILDREN : Doses are given every 6 hours 
( maximum 1.2gm in 24 hours) 
Below 1 year: 112 teaspoonful or 1/2 suppository. 
1-3 years:112 - 1 teaspoonful or 1/2 - 1 suppository. 
3-6 years: 1 teaspoonful or 1 suppository. 
6-12 years :2 teaspoonfuls or 1/2 tablet. 
Packing: Tablets : Boxes of 20 8 1000 tablets 
Syrup; Bottles of 608 125 ml. 
Suppositories ; Boxes of 5 Suppositories.

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