Saturday, September 14, 2013

Lohydran

Lohydran 
L1O1O3OA-7/09 Lohydran Powder for oral rehydration solution Composition:
Each packet (4.1 g) contains:
Sodium chloride 0.520 g.
Triaodium citrate dihydrate 0.580 g.
Potassium chloride 0.300 g.
Glucose anhydroua 2.700 g.
Pharmacological action:
Lohydran powder for oral rehydration solution is wall balanced formula consisting of sugar-and salts to replace body fluids and electrolytes lost as a result of diarrhea.
- Sodium chloride & Potassium chloride : replace electrolyte deficit adequately end safely.
-Glucose : enhance absorptioli of electrolytes and water from the intestine.
- Potassium citrate: added to revert metabolic acidosis
Lohydran ia characterised by its orange flavour taste which make it palatable and acceptable especially to children in addition to its easily usage in hospital and at home.
Pharmacokinetics:
- Sodium chloride & Potassium chloride: are readily absorbed from the gastrointestinal tract escreted mainly by the kidney and some ara lost in the faeces and sweat.
- Glucose : readily absorbed from the gastrointestinal tract metabolized via pyruvic or lactic acid to carbon dioxide and water with release of energy.
- Potassium citrate: metabolized after absorption to bicarbonate.
Indications:
- Treatment of dehydration caused by gastroenteritis or diarrhea.
- Excessive looses of electrolytes in the faeces e.g. chronic disrrhes associated with intestinal mslsbsorption or lexative abuse.
Contra- Indication:
Gastrointestinal tract obstruction.
Side Effects:
Vomiting can occur after taking oral rehydretion solution, this may indicate that it was given too quickly. If vomiting occur, adminisfration should be halted for 10 minutes then resumed in smaller, more frequent amounts.
Drug Interactions:
Not known.
Warnings & Precautions:
- Caution is required in the following cases:
- kidney disease (including people who are producing very small amounts or no urine).
- Liver disease.
- People on low sodium or potassium diet.
- Diabetes.
- Severe end persistent diarrhes and vomiting.
- For infants only breast-feeding or formula feed should be continued during the hours of rehydretion therapy.
- Pregnancy and lactation: Lohydren can be used safely during
pregnancy end lactation.
Dosage & Administration:
- Dissolve the contents of the packet in 200 ml fresh water (previously boiled and cooled water for infants) end given slowly by using a spoon.
- Don’ t boil the prepared solution
- The solution should be made up immediately before use end used within one hour. If refrigerated the solution should be used within 24 hours only.
Usual dose: 200400 ml solution sEer every loose stool.
Infants: 1-1½ times usual feed volume.
Child: 200 ml solution after every loose stool.
NB: once rehydration is complete the patient should drink normal volume of fluids in infant bmsst feeding or formula feed should be offered between oral rehydrstion drink.
Packing’.
&ox of 10 packets.
Storage:
Keep sway from moisture & at temp. not exceeding 30°C.
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Produced by: Chemical Industries Development (CID) - Gize - ARE.
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