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| All-Vent |
All-Vent Syrup Bronchodilator, Mucolytic
Expectorant & Demulcent Sugar & Dye f ree
with the natural taste of menthol Composition: Each 5 ml of All-Vent syrup contains: - Bromhexine hydrochloride 4 mg - Terbutaline sulphate 1.25 mg - Guaifenesin 50 mg - Menthol 2.5 mg
Properties: All-Vent syrup has the advantage of combining four active ingredients namely; Bromhexine hydrochloride, (mucolytic), Guaifenesin (expectorant), Terbutaline sulphate (bronchodilator) in addition to menthol that offers a great cooling sensation in a specially formulated vehicle that gives the final preparation the advantages of being sugar free, dye free and naturally menthol flavored. This widens the scope of its application to allergic asthmatic type patients as well as diabetics.
Mechanisms of action of the four ingredients are as follows
Bromhexine hydrochloride : is a mucolytic agent, which liquifies thick, tenacious sputum. Viscosity of sputum is reduced by dissolving mucopolysaccharide fibers, It also improves mucociliary clearance of secretions.
Guaifenesin : is an expectorant. It increases the output of sputum and bronchial secretions by reducing adhesiveness and surface tension. By increasing the volume of bronchial secretions, it reduces the viscosity of tenacious sputum. The increased flow of less viscid secretions also promotes ciliary action.
Terbutaline sulphate : is a directly acting sympathomimetic agent with selective 12- stimulant effect. 12-agoinsts help alleviate bronchospasm associated with cough, relief bronchospasm, and facilitates drainage of accumulated secretions.
Menthol: acts as a demulcent and soothing agent.
Expectorant & Demulcent Sugar & Dye f ree
with the natural taste of menthol Composition: Each 5 ml of All-Vent syrup contains: - Bromhexine hydrochloride 4 mg - Terbutaline sulphate 1.25 mg - Guaifenesin 50 mg - Menthol 2.5 mg
Properties: All-Vent syrup has the advantage of combining four active ingredients namely; Bromhexine hydrochloride, (mucolytic), Guaifenesin (expectorant), Terbutaline sulphate (bronchodilator) in addition to menthol that offers a great cooling sensation in a specially formulated vehicle that gives the final preparation the advantages of being sugar free, dye free and naturally menthol flavored. This widens the scope of its application to allergic asthmatic type patients as well as diabetics.
Mechanisms of action of the four ingredients are as follows
Bromhexine hydrochloride : is a mucolytic agent, which liquifies thick, tenacious sputum. Viscosity of sputum is reduced by dissolving mucopolysaccharide fibers, It also improves mucociliary clearance of secretions.
Guaifenesin : is an expectorant. It increases the output of sputum and bronchial secretions by reducing adhesiveness and surface tension. By increasing the volume of bronchial secretions, it reduces the viscosity of tenacious sputum. The increased flow of less viscid secretions also promotes ciliary action.
Terbutaline sulphate : is a directly acting sympathomimetic agent with selective 12- stimulant effect. 12-agoinsts help alleviate bronchospasm associated with cough, relief bronchospasm, and facilitates drainage of accumulated secretions.
Menthol: acts as a demulcent and soothing agent.
I’I Pharmacokinetics:
Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and about 85 to 90 % of the dose is excreted in the urine, mainly as metabolites. One of these ambroxol is a pharmacologically active, with actions similar to the parent compound. Bromhexine hydrochloride is highly bound to plasma proteins.
Gualfenesin is absorbed from the gastrointestinal tract. It is metabolized and excreted in the urine,
Terbutaline sulphate is variably absorbed from the gastrointestinal tract and is subjected to fairly extensive first pass metabolism. There are no known active metabolites. Terbutaline has half life of 3-4 hours. It is excreted in the urine partly as inactive conjugates and partly as unchanged terbutaline. Indications
All-Vent syrup is indicated in the treatment of productive cough when associated with bronchospasm in conditiorts such as:
• Bronchitis and bronchial asthma.
• Chronic obstructive pulmonary disease
(COPD).
• Bronchiectasis.
• Emphysema. Dosage and administration: All-Vent is usually given times a day in the following doses:
• Adults:
2 teaspoonfuls (10 ml).
• Children: - (6-12 years):1 teaspoonful (5 ml) - (2-6 years): 112 teaspoonful (2.5 ml) Side effects: The most commonly observed side effects are tremor and nervousness. The frequency of these side effects appear to diminish with continued therapy.
Other commonly reported reactions include increased heart rate, palpitations, dizziness, headache, drowsiness, vomiting, nausea, sweating and muscle cramps.
These reactions are generally transient and usually do not require treatment.
There have been rare reports of elevations in liver enzymes and of hypersensitivity vasculitis.
Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and about 85 to 90 % of the dose is excreted in the urine, mainly as metabolites. One of these ambroxol is a pharmacologically active, with actions similar to the parent compound. Bromhexine hydrochloride is highly bound to plasma proteins.
Gualfenesin is absorbed from the gastrointestinal tract. It is metabolized and excreted in the urine,
Terbutaline sulphate is variably absorbed from the gastrointestinal tract and is subjected to fairly extensive first pass metabolism. There are no known active metabolites. Terbutaline has half life of 3-4 hours. It is excreted in the urine partly as inactive conjugates and partly as unchanged terbutaline. Indications
All-Vent syrup is indicated in the treatment of productive cough when associated with bronchospasm in conditiorts such as:
• Bronchitis and bronchial asthma.
• Chronic obstructive pulmonary disease
(COPD).
• Bronchiectasis.
• Emphysema. Dosage and administration: All-Vent is usually given times a day in the following doses:
• Adults:
2 teaspoonfuls (10 ml).
• Children: - (6-12 years):1 teaspoonful (5 ml) - (2-6 years): 112 teaspoonful (2.5 ml) Side effects: The most commonly observed side effects are tremor and nervousness. The frequency of these side effects appear to diminish with continued therapy.
Other commonly reported reactions include increased heart rate, palpitations, dizziness, headache, drowsiness, vomiting, nausea, sweating and muscle cramps.
These reactions are generally transient and usually do not require treatment.
There have been rare reports of elevations in liver enzymes and of hypersensitivity vasculitis.
Bromhexine : gastrointestinal side effects may occur occasionally with brornhexine and a transient rise in serum aminotransferase values has been reported.
Guaifenesin : gastrointestinal discomfort has occasionally been reported with guaifenesin. Very large doses cause nausea and vomiting. Terbutaline : the adverse reactions of terbutaline sulphate are similar to those of other sympathomimetic agents, Warning and precautions: While treating cough as a symptom, it is important to make every effort to determine and treat appropriately the underlying cause, such as a specific infection.
Caution should be observed while prescribing All-Vent to patients with hypertension, cardiovascular disease (induding arrhythmias, coronary insufficiency) uncontrolled diabetes mellitus and patients with hyperthyroidism, patients with history of seizures, or in patients who are unusually responsive to syrnpathomimetic amines.
Patients susceptible to hypokalemia should be monitored because transient early falls in serum potassium levels have been reported with 3-agonists.
Since mucolytica, such as bromhexine, may disrupt the gastric mucosal barrier, Bromhexine should be used with care in patients with a history of peptic ulcerstion. Pregnancy and lactation: Safety of All-Vent has not been studied in pregnant and lactating women Therefore, probable benefits should be weighed against possible risks before prescribing All-Vent during pregnancy and lactation. Contraindications: This medication is contraindicated for patients with a history of hypersensitivity to sympathetic amines and any other components in the preparation. Drug interactions: • Adverse metabolic effects of high dose 12- agonist such as terbutaline may be exacerbated by concomitant administration of high doses of corticosteroids.
• Hypokalemia with high doses of 12- agonists may results in increased susceptibility to digitalis induced cardiac arrhythmias.
Guaifenesin : gastrointestinal discomfort has occasionally been reported with guaifenesin. Very large doses cause nausea and vomiting. Terbutaline : the adverse reactions of terbutaline sulphate are similar to those of other sympathomimetic agents, Warning and precautions: While treating cough as a symptom, it is important to make every effort to determine and treat appropriately the underlying cause, such as a specific infection.
Caution should be observed while prescribing All-Vent to patients with hypertension, cardiovascular disease (induding arrhythmias, coronary insufficiency) uncontrolled diabetes mellitus and patients with hyperthyroidism, patients with history of seizures, or in patients who are unusually responsive to syrnpathomimetic amines.
Patients susceptible to hypokalemia should be monitored because transient early falls in serum potassium levels have been reported with 3-agonists.
Since mucolytica, such as bromhexine, may disrupt the gastric mucosal barrier, Bromhexine should be used with care in patients with a history of peptic ulcerstion. Pregnancy and lactation: Safety of All-Vent has not been studied in pregnant and lactating women Therefore, probable benefits should be weighed against possible risks before prescribing All-Vent during pregnancy and lactation. Contraindications: This medication is contraindicated for patients with a history of hypersensitivity to sympathetic amines and any other components in the preparation. Drug interactions: • Adverse metabolic effects of high dose 12- agonist such as terbutaline may be exacerbated by concomitant administration of high doses of corticosteroids.
• Hypokalemia with high doses of 12- agonists may results in increased susceptibility to digitalis induced cardiac arrhythmias.
Hypokalemia may be enhanced by concomitant administration of aminophylline or other xanthines, corticosteroids or by diuretic therapy.
Terbutaline reduces serum theophylline concentrations by increasing its systemic clearance. This may or may not have clinical implications as improved clinical scores have still occured with combined therapy despite the theophylline concentrations being lower than when used alone. If respiratory symptoms persist, an increase in dosage may be contemplated while monitoring theophylline side-effects and concentration.
Other sympathomimetic bronchodilators or epinephrine should not be used concomitantly with terbutaline sulphate since their combined effect on cardiovascular system may be deleterious to the patient This recommendation does not preclude the iudicious use of an aerosol bronchodilator of the adrenergic stimulant type in patients receiving All-Vent.
Terbutaline sulphate should be administered with caution in patients being treated with MAO inhibitors (as Furazolidone) or tricyclic antidepressants, since the action of terbutaline sulphate on the vascular system may be potentiated.
112-adrenergic receptor blocking agents not only block the pulmonary effect of terbutaline but may produce severe asthmatic attacks in asthmatic patients. Therefore, patients requiring treatment for both bronchospastic disease and hypertension should be treated with medication other than It-adrenergic blocking agents for hypertension. Storage and presentation: - Bottle of 125 ml.
- Store at a temperature not exceeding 30°C.
Terbutaline reduces serum theophylline concentrations by increasing its systemic clearance. This may or may not have clinical implications as improved clinical scores have still occured with combined therapy despite the theophylline concentrations being lower than when used alone. If respiratory symptoms persist, an increase in dosage may be contemplated while monitoring theophylline side-effects and concentration.
Other sympathomimetic bronchodilators or epinephrine should not be used concomitantly with terbutaline sulphate since their combined effect on cardiovascular system may be deleterious to the patient This recommendation does not preclude the iudicious use of an aerosol bronchodilator of the adrenergic stimulant type in patients receiving All-Vent.
Terbutaline sulphate should be administered with caution in patients being treated with MAO inhibitors (as Furazolidone) or tricyclic antidepressants, since the action of terbutaline sulphate on the vascular system may be potentiated.
112-adrenergic receptor blocking agents not only block the pulmonary effect of terbutaline but may produce severe asthmatic attacks in asthmatic patients. Therefore, patients requiring treatment for both bronchospastic disease and hypertension should be treated with medication other than It-adrenergic blocking agents for hypertension. Storage and presentation: - Bottle of 125 ml.
- Store at a temperature not exceeding 30°C.
Produced by BORG PHARMACEUTICAL IND. Borg El-Arab new city - Industrial zone 3
District 17- area no. 3
Alexandria - Egypt
District 17- area no. 3
Alexandria - Egypt
Keep all medicaments out of reach of children I
BORG PHARMACEUT
ICAL IND. BORG PHARMACEUTICAL IND. BORG PHA
RMACEUTICAL IND.I
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