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| Larogen |
Larogen Rest of pamphlet
Composition:
Each tablet contains:
Lamotrigine.100 mg
Lamotrigine 25 mg
Properties:
lamotrigine inhibits voltage -sensitive Na channels to stabilize neuronal membrane and inhibit neurotransmitter release
Indications:
Add-on therapy: Larogen is indicated as add-on therapy in partial epilepsy with or without secondary generalized tonic-clonic seizures and in primary generalized tonic-clonic seizures and the seizures associated with Lennox-Gastaut syndrome in pediatric and adult patients.
Monotherapy: Larogen is indicated for the conversion to monotherapy in adults with partial seizures who are recieving treatment with single EIADs (enzyme inducing
antiepileptic drugs).
Contraindications:
1 -hypersensitivity
2-patients with significant hepatic or renal failure
Precautions:
Serious skin rash has been reported especially with rapid titration, although most rashes resolved even with continuation of treatment with lamotrigine, It is not possible to predict reliably which rashes will prove to be serious. Accordingly, lamotrigine should be
discontinued at the first sign of rash, unless the rash is clearly is not drug
related.discontinuation of treatment may not prevent rash from becoming disabling or disfiguring.
Composition:
Each tablet contains:
Lamotrigine.100 mg
Lamotrigine 25 mg
Properties:
lamotrigine inhibits voltage -sensitive Na channels to stabilize neuronal membrane and inhibit neurotransmitter release
Indications:
Add-on therapy: Larogen is indicated as add-on therapy in partial epilepsy with or without secondary generalized tonic-clonic seizures and in primary generalized tonic-clonic seizures and the seizures associated with Lennox-Gastaut syndrome in pediatric and adult patients.
Monotherapy: Larogen is indicated for the conversion to monotherapy in adults with partial seizures who are recieving treatment with single EIADs (enzyme inducing
antiepileptic drugs).
Contraindications:
1 -hypersensitivity
2-patients with significant hepatic or renal failure
Precautions:
Serious skin rash has been reported especially with rapid titration, although most rashes resolved even with continuation of treatment with lamotrigine, It is not possible to predict reliably which rashes will prove to be serious. Accordingly, lamotrigine should be
discontinued at the first sign of rash, unless the rash is clearly is not drug
related.discontinuation of treatment may not prevent rash from becoming disabling or disfiguring.
Lamotrigine can cuse
aseptic meningitis. Symptoms of meningitis may
include headache, stiff neck,nausea,vomiting, rash and sensivity to light. In cases of meningitis, it is important to rapidly diagnose the underlying cause so that treatment can be promptly initiated.
Patients should be advised to contact their healthcare professional immediately if the experience signs & symptoms of meningitis while taking lamotrigine .if meningitis suspected . patients should be evaluated for other causes of meningitis and treated as indicated. Discontinuation of lamotrigine should be considered if no other clear of meningitis is identified.
Warning:
Cases of life-threatening serious rashes, including stevens-johnson syndrome, toxic epidermal necrolysis, andlor rash-related death, have been caused by lamotngine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:
Coadminstation with valproate
Exceeding recommended initial dose of lamotrigine
Exceeding recommended dose escalation of lamotrigine
Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. lamotrigme should be discontinued at the first sign of rash, unless the rash is clearly not drug-related.
include headache, stiff neck,nausea,vomiting, rash and sensivity to light. In cases of meningitis, it is important to rapidly diagnose the underlying cause so that treatment can be promptly initiated.
Patients should be advised to contact their healthcare professional immediately if the experience signs & symptoms of meningitis while taking lamotrigine .if meningitis suspected . patients should be evaluated for other causes of meningitis and treated as indicated. Discontinuation of lamotrigine should be considered if no other clear of meningitis is identified.
Warning:
Cases of life-threatening serious rashes, including stevens-johnson syndrome, toxic epidermal necrolysis, andlor rash-related death, have been caused by lamotngine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:
Coadminstation with valproate
Exceeding recommended initial dose of lamotrigine
Exceeding recommended dose escalation of lamotrigine
Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. lamotrigme should be discontinued at the first sign of rash, unless the rash is clearly not drug-related.
Lamotrigine 25 mg & 100
mg
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