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Urosolvine Effervescent Granules

Urosolvine Effervescent Granules
Urosolvine Effervescent Granules
For management of urolithiasis and gouty arthritis
P 1
Each 5 g (sachet) contains:
Active ingredients:
Piperazine Citrate 0.1408 g
(Eq. To 0.128 g .Piperazine Hydrate)
Coichicine Crystals 0.3 mg
Atropine Sulphate 0.128 mg
Inactive Ingredients:
Sod.Bicarbonak ,Citric acid anhy., Tartaric acid, Lemon oil, Sucrose.
Pharmaceutical form: Effervescent Granules
Pharmacotherapeutic group : Uricosuric
Pharmacological action:
- An acute attack of gout apparently occurs as a result of increasing uric acid concentration that results in deposition of monosodium urate in the joint tissue.
- Piperazine known for many ‘ears to be an active drug in the treatment of gout and urinary lithiasis. It is claimed to increase the solubilitv of urates in the urine. It is relatively non- toxic.
- Colchicine gives rapid relief from pain in acute attacks of gout and the drug is specific for this condition to (he extent that it can he used as a diagnostic agent in gout and gouty arthritis. Colchicinc possesses anti-inflammatory properties. Although it is highly effective in treating acute gouty arthritis, it is not effective for other types of pain. It is not an analgesic and does not affect uric acid clearance. Insteadcolchicine binds to proteins in microtubules of neutrophils. This binding.in turn. inhibits the migration of neutrophils into the area of inflammation, thereby interfering with the inflammatory response to urate crystal deposition.Atropine sulphate is added to relieve the spasm of the urinary tract.
Ph ar macoki net ics:
- Urosolvine contains a typical uricosuric agent that promotes the urinary excretion of uric acid and thereby lower
serum uric acid concentration
- Sodium citrate is an alkalinising agent since the citrate is converted into bicarbonate , alkaline urine is definitely more
suitable for the excretion of uratcs in a more soluble form.
Indications:
-Acute and chronic gout
-Goutv arthritis
-For prophylaxis against urinary lithiasis ( urate stones).
Dosage and administration:
- In acute attack: one sachet dissolved in a half glass of water 6 times daily.
- To prevent acute attack: 2 sachetstlissolved in a glass of water 2 times daily.
- As a prophylaxis : 2 sachets dissolved in a glass of water once daily.
Contraindications:
-Known hypersensitivity to any of the components of the drug.
-Blood dyscrasias
-Acute deh’vdrationanuria or hyperkalemia
Side effects: Occasionally nausea, vomiting,abdominal pain and diarrhea may occur.
Drug interactions: None.
Pregnancy and lactation:
- Contraindicated in pregnant women.
- It is unknown if drug appears in breast milk.
Precautions and warnings:
- Used with caution in patients with serious GIT. renal, hepatic, and cardiovascular disorders.
- It should not be used in children , geriatrics, debilitated patients and nursing women _____________________
This ISA MEOICAMENT
Package and storage: 1/2
- Carton box of 12 SachctsX 5 g i-inner leaflet. 2/20 11
-. . . & a.O ba .11*. pI.nal ..
-
Store at temperature not exceeding 25 UC in a dry place. Code No
fl_ ——
451006
Instructions to patients:
- Reduce dosage if vomiting or diarrhea occurs.
I r

Manufactured by The NILE Co. for Pharmaceuticals and
Chemical Industries
- Cairo -A.R.E. R.C.C. 115668

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