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Bronchalin

Disclaimer: This information is for educational purposes and is not a substitute for professional medical advice. Bronchaline is a potent combination medication with a narrow therapeutic window and significant side effects. It should only be used under the strict supervision of a doctor.


Bronchaline: A Guide to the Combination Asthma Medication

Manufacturer: CID (Chemical Industries Development), Giza, Egypt

Category: Combination Anti-Asthmatic (Bronchodilator, Decongestant, Antihistamine)

Active Ingredients (per tablet):

  • Theophylline anhydrous: 120 mg
  • Ephedrine hydrochloride: 15 mg
  • Hydroxyzine hydrochloride: 10 mg

Available Form: Box of 20 tablets.

Summary

Bronchaline is a combination oral medication used in the management of bronchial asthma. It contains three active ingredients designed to work together to relax the airways, reduce congestion, and manage allergic and anxiety components of an asthma attack. It is important to note that while historically common, this type of oral combination therapy is generally considered a second-line or older treatment approach according to modern international asthma guidelines.

Mechanism of Action: A Triple-Action Formula

Bronchaline aims to relieve asthma symptoms through three distinct mechanisms:

  1. Theophylline (The Primary Bronchodilator): This is a methylxanthine drug that directly relaxes the smooth muscles of the bronchi (airways) and the pulmonary blood vessels, helping to open up the airways and make breathing easier.
  2. Ephedrine (The Decongestant & Secondary Bronchodilator): This is a sympathomimetic agent that stimulates adrenergic receptors. It provides additional bronchodilation and, importantly, reduces swelling and congestion in the bronchial mucosa (the lining of the airways).
  3. Hydroxyzine (The Sedating Antihistamine): This is a first-generation antihistamine. It is included for several reasons: to manage any allergic triggers of asthma, to provide its own mild bronchodilator effect, and, crucially, to counteract the stimulating side effects (like nervousness and tremor) of Theophylline and Ephedrine with its calming, anti-anxiety action.

Therapeutic Indication: When is Bronchaline Used?

The primary indication for Bronchaline is the symptomatic relief and management of **Bronchial Asthma**. It is used to relieve bronchospasm and improve pulmonary ventilation.

Dosage and Administration

The typical dosage for adults is **one tablet, taken 3 to 6 times daily**, depending on the severity of the condition and as directed by a physician. The frequency and dose must be carefully managed due to the narrow therapeutic index of Theophylline.

Key Contraindications, Warnings, and Side Effects

  • Modern Context: Bronchaline is not a first-line treatment for asthma. Modern therapy prioritizes inhaled corticosteroids and selective beta-2 agonists, which have a better safety profile.
  • Narrow Therapeutic Index: Theophylline levels in the blood must be kept within a specific range. Too little is ineffective, and too much can be toxic, causing seizures or life-threatening heart rhythm problems.
  • Cardiovascular Risks: Due to Ephedrine and Theophylline, this medication should be used with extreme caution in patients with hypertension, heart disease, or hyperthyroidism. It can cause a rapid heart rate, palpitations, and increased blood pressure.
  • Drowsiness: Hydroxyzine is a potent sedative. Patients taking Bronchaline should not drive, operate heavy machinery, or perform tasks requiring mental alertness until they know how the medication affects them.
  • Drug Interactions: Theophylline has numerous significant drug interactions (e.g., with cimetidine, ciprofloxacin, erythromycin) that can dangerously increase its levels. Always inform your doctor of all other medications you are taking.

Frequently Asked Questions (FAQ)

Is Bronchaline a "reliever" or a "preventer" inhaler?
Bronchaline is neither. It is an oral tablet designed for ongoing management of asthma symptoms, not for rapid relief of an acute attack (like a blue "reliever" inhaler) or for long-term inflammation control (like a "preventer" inhaler). It is part of an older treatment paradigm.

Why does this asthma medication make me drowsy?
The drowsiness is caused by Hydroxyzine, a sedating antihistamine. It is intentionally included in the formula to help counteract the stimulating, "jittery" side effects that can be caused by the other two ingredients, Theophylline and Ephedrine.

Is this medication still commonly prescribed for asthma?
In many parts of the world, and according to major international guidelines, this type of oral combination therapy has been largely replaced by inhaled medications (like corticosteroids and selective bronchodilators) which deliver the drug directly to the lungs with fewer systemic side effects and a better safety profile. However, it may still be prescribed in certain situations or regions.

Sources

  1. Theophylline Professional Information - Drugs.com
  2. Ephedrine Professional Information - Drugs.com
  3. Global Initiative for Asthma (GINA) Reports
  4. Official Product Leaflet for Bronchaline.

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