ACIVIRAX (Acyclovir) Tablets: A Guide for Herpes and Shingles

MEDICAL INFORMATION: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

ACIVIRAX® (Acyclovir) Tablets

Summary

ACIVIRAX is an antiviral medication containing the active ingredient Acyclovir. It is used to treat infections caused by the Herpes Simplex Virus (HSV), such as genital herpes and cold sores, and the Varicella-Zoster Virus (VZV), which causes chickenpox and shingles. ACIVIRAX works by stopping the virus from replicating, which helps to reduce the severity and duration of the outbreak and allows the body's immune system to control the infection. It is most effective when started at the very first sign of an outbreak.

Manufacturer

Mash Premiere For Pharmaceutical Industry, Egypt.

Category & Active Ingredient

• Category: Antiviral Agent (Synthetic Nucleoside Analogue).
• Active Ingredient: Acyclovir.

Available Forms & Strengths in Egypt

ACIVIRAX is available as oral tablets in the following strengths:

• ACIVIRAX 400 mg Tablets
• ACIVIRAX 800 mg Tablets

Properties and Mechanism of Action

Acyclovir is a synthetic nucleoside analogue that is highly selective for virus-infected cells. It is converted into its active form, acyclovir triphosphate, by a viral enzyme called thymidine kinase. This active form then interferes with the viral DNA polymerase, an enzyme essential for the virus to copy its genetic material. By blocking this enzyme, Acyclovir effectively halts viral replication without significantly affecting normal human cells.

Indications for ACIVIRAX® Tablets

ACIVIRAX tablets are used for:

• Treatment of Genital Herpes: For managing initial episodes and for recurrent outbreaks.
• Suppressive Therapy for Genital Herpes: For long-term use to reduce the frequency of recurrences in patients with frequent outbreaks.
• Treatment of Shingles (Herpes Zoster): To reduce the duration of the rash and pain.
• Treatment of Chickenpox (Varicella): Especially in adolescents, adults, and immunocompromised individuals.
• Treatment of Cold Sores (Herpes Labialis).

Dosage and Administration

Dosage varies significantly depending on the type of infection, the patient's age, and their kidney function. It is crucial to follow the doctor's prescription exactly.

• For Shingles: A common adult dose is 800 mg five times a day for 7-10 days.
• For Genital Herpes Treatment: A common adult dose is 400 mg three times a day for 7-10 days.
• For Suppressive Therapy: A common adult dose is 400 mg twice a day.
• Hydration: It is important to drink plenty of water while taking Acyclovir to help protect the kidneys.

Side Effects

While generally well-tolerated, side effects can occur.

• Common: Nausea, vomiting, diarrhea, headache, and a general feeling of being unwell (malaise).
• Less Common: Skin rashes, dizziness.
• Rare but Serious: In patients with poor kidney function or in the elderly, neurological side effects like confusion or hallucinations can occur. Kidney problems can also arise, especially with high doses or dehydration.

Contraindications

ACIVIRAX is contraindicated in patients with a known hypersensitivity to Acyclovir or Valacyclovir.

Precautions & Warnings

• Renal Impairment: The dose must be reduced in patients with kidney problems, as the drug is cleared by the kidneys.
• Hydration: Maintaining good hydration is essential to prevent the drug from forming crystals in the kidneys.
• Elderly Patients: The elderly are more susceptible to neurological side effects and may require dose adjustments.
• Starting Treatment: For best results, treatment should begin as soon as possible after the first symptoms of an outbreak appear.

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Acyclovir is also available as an intravenous (IV) infusion for severe infections. To compare different Acyclovir brands and forms available in Egypt, please visit our comprehensive guide and comparison hub.

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Frequently Asked Questions (FAQ)

Is ACIVIRAX a cure for herpes?
No. Acyclovir is a treatment, not a cure. It helps to manage outbreaks by stopping the virus from multiplying, but it does not eliminate the virus from the body. The virus remains dormant and can reactivate later.

What is the difference between the 400 mg and 800 mg tablets?
They contain the same active ingredient but at different strengths. The 800 mg tablets are typically used for treating shingles, which requires a higher dose, while the 400 mg tablets are often used for genital herpes. This allows for more convenient dosing schedules.

Can I take ACIVIRAX if I'm pregnant?
The use of Acyclovir during pregnancy should be discussed with a doctor. It is generally considered for use only if the potential benefit justifies the potential risk to the fetus. A pregnancy registry has not shown an increase in birth defects.

References

1. U.S. National Library of Medicine (MedlinePlus): For patient-friendly information on Acyclovir. Acyclovir - MedlinePlus
2. British National Formulary (BNF) - NICE: For professional information on Acyclovir dosing and indications. Aciclovir - NICE
3. Product Information: Sourced from the manufacturer, Mash Premiere.