Mixderm Cream

Disclaimer: This information is for educational purposes and is not a substitute for professional medical advice. Mixderm is a potent combination medication that should only be used under the strict supervision of a doctor and for the shortest duration possible.

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Mixderm Cream: A Complete Guide to the Quadruple-Action Skin Cream

Manufacturer: Manufactured by October Pharma for SIGMA Pharmaceutical Industries.

Category: Combination Topical Corticosteroid, Antibiotic, and Antifungal

Active Ingredients (per gram):

• Betamethasone valerate (0.5 mg): A potent corticosteroid.
• Gentamicin sulphate (1.0 mg): A broad-spectrum antibiotic.
• Tolnaftate (10 mg): An antifungal agent.
• Clioquinol (10 mg): An antifungal and antibacterial agent.

Available Form: Cream in 15 g and 30 g tubes.

Summary

Mixderm Cream is a powerful, multi-ingredient topical preparation designed to treat inflamed skin conditions (dermatoses) that are either complicated by a secondary infection or are at risk of becoming infected. It provides a "shotgun" approach by combining four active ingredients: a potent steroid to fight inflammation and itching, a powerful antibiotic to kill bacteria, and two different antifungal agents to treat a wide range of fungal and yeast infections.

Mechanism of Action: A Four-in-One Approach

Mixderm's effectiveness comes from its four components working simultaneously:

1. Betamethasone (Anti-inflammatory): A potent corticosteroid that rapidly reduces inflammation, redness, swelling, and itching associated with skin conditions like eczema and dermatitis.
2. Gentamicin (Antibacterial): A broad-spectrum antibiotic that kills a wide variety of bacteria that can cause secondary skin infections.
3. Tolnaftate (Antifungal): A specific fungicidal agent that is highly effective against the types of fungi that cause tinea infections (ringworm), such as athlete's foot (tinea pedis) and jock itch (tinea cruris).
4. Clioquinol (Antifungal/Antibacterial): An older agent that has activity against both fungi and some bacteria, providing an additional layer of antimicrobial coverage.

Therapeutic Indications: When is Mixderm Used?

Mixderm is indicated for corticosteroid-responsive dermatoses when complicated by, or at risk of, secondary bacterial and/or fungal infections. Such disorders include:

• Infected eczema or dermatitis (atopic, contact, seborrheic).
• Intertrigo (inflammation in skin folds).
• Neurodermatitis (lichen simplex chronicus).
• Impetigo, folliculitis.
• Tinea infections (ringworm) that are severely inflamed, such as tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm of the body).

Dosage and Administration

A thin film of Mixderm cream should be applied to completely cover the affected area two or three times daily, as prescribed by a physician. The frequency and duration of therapy depend on the severity and nature of the condition. For fungal infections like tinea pedis, a longer duration of therapy (2-4 weeks) may be necessary.

Key Contraindications, Warnings, and Side Effects

• Contraindications: A history of hypersensitivity to any of the components. Not for use on simple, non-infected skin conditions.
• Corticosteroid Side Effects: This is the most significant risk. Prolonged use of this potent steroid can lead to skin thinning (atrophy), stretch marks (striae), acne-like eruptions, and hypopigmentation (lightening of the skin).
• Systemic Absorption: Using Mixderm on large areas of skin, for prolonged periods, or under occlusion (e.g., under a diaper or bandage) can lead to systemic absorption of the steroid and antibiotic, which can cause significant side effects, especially in infants and children.
• Staining: The Clioquinol in Mixderm can cause a yellowish stain on skin and clothing.
• Ophthalmic Use: Mixderm is for external skin use only and must NEVER be used in or around the eyes.

Frequently Asked Questions (FAQ)

Why does Mixderm have four active ingredients?

It's designed for complex situations where a doctor suspects both inflammation and a mixed infection (bacterial and/or fungal). It provides broad coverage to treat all potential causes simultaneously. However, because of its potency, it should only be used when necessary and for a limited time.

Can I use Mixderm for a simple diaper rash?

No. Using a potent steroid combination like Mixderm for a simple diaper rash is not recommended and can be harmful. The skin in the diaper area is thin and under occlusion, which increases absorption and the risk of side effects. A simple barrier cream or a milder anti-inflammatory should be used unless prescribed by a doctor for a severe, complicated rash.

Will Mixderm stain my clothes?

Yes, it is very likely. The active ingredient Clioquinol is known to leave a yellow stain on skin, nails, and fabric. It is advisable to wear older clothing or use a protective dressing over the area after application to avoid staining.

Sources

1. Mixderm Information - Drugs.com
2. Betamethasone - StatPearls, NCBI
3. Official Product Leaflet for Mixderm.