 |
| Declophen |
DECL0PHEN Antirheumatic
Tablets 25 and 50 mg, Anti-inflammatory
Ampoules ( IM) and Suppositories Analgesic - Antipyretic
Tablets 25 and 50 mg, Anti-inflammatory
Ampoules ( IM) and Suppositories Analgesic - Antipyretic
Composition:
Each formulation contains: tablet ampoule suppository
Diclofenac sodium 25 mg or 50 mg 75 nigl3 ml 100mg
Properties:
DECLOPHEN (didofenac sodium) is a nonsteroidal drug with antirheumatic, anti-inflammatory, _________ analgesic and antipyretic properties. DECLOPHEN effectively inhibits cyclooxygenase synthetic _________ pathway of prostaglandins responsible for inflammation, pain and lever in various rheumatic and non- _________ rheumatic conditions, Clinically, DECLOPHEN relieves manifestations of inflammation in rheumatoid __________ arthritis, ankylosing spondytitis, gouty arthritis and osteoarthritis with relief of musculoskeletal pain __________ and associated fever. DECLOPHEN is also highly effective in overcoming joint inflammation, swelling
and morning stiffness with improvement of joint mobility and function. In non-rheumatic conditions, _____ DECLOPHEN exerts a potent analgesic effect relieving post-operative-and post-traumatic pain, and pain associated with sport injuries and gynecological conditions. DECLOPHEN also effectively relieves biliary and renal colic. DECLOPHEN is available in three different dosage forms (tablets, ampoules and suppositories) to cover a wide spectrum of clinical applications in acute and chronic diseases of joints, muscles and bones with excellent safety and patient compliance.
Pharmacokinetlcs:
Following administration of DECLOPHEN tablets, ampoules (IM) or suppositories, diclofenac is rapidly absorbed from the site of administration. Peak plasma concentrations are achieved within 1.5 2 hours after oral administration and much faster following (IM) injection, Diclofenac is highly distributed in body tissues and fluids, and concentrations equivalent to those in plasma are rapidly reached in the synovial fluid and persist much longer. The crug is 99% bound to plasma proteins and is metabozed in the liver. Diclofenac is excreted mainly as metabolites in urine (>60%) and in the bile (>30%) with mean plasma half-life of 1-2 hours. The drug crosses the placenta and trace amounts appear in breast milk.
Indications:
- Osteoarthritis.
- Rheumatoid arthritis. )
- Ankylosing spondylitis.
- Gouty arthritis.
- Painful shoulder resulting from peritendinitis, capsulitis, bursitis and acute arthritis.
• Non-articular rheumatism.
• Post-operative pain, sport injuries and post-traumatic painful and inflammatory conditions.
- Primary dysmenormhea and other painful gynecological conditions.
- Bihary and renal colic.
Dosage:
Tablets: 1 -2 DECLOPHEN 25 Tablets three times daily or one DECLOPHEN 50 Tablet, 2 - 3 times daily or as directed by the physician.
Ampoules (IM) : one DECLOPHEN ampoule daily or every 12 hours according to severity of the condition or as directed by the physician.
Suppositories : one DECLOPHEN suppository daily at bedtime or as directed by the physician.
Contraindications:
Hypersensitivity to cliclofenac and active peptic ulcer.
Precautions:
As with other nonsteroidal anti-inflammatory drugs (NSAIOs), DECLOPHEN should be given with care to patients receiving oral anticoagulants. Renal function must be evaluated during long-term therapy. Side Effects:
DECLOPHEN is safe and well-tolerated. Mild and infrequent GI disturbances (epigastric pain, nausea), skin rash, pruritus, malaise, headache or edema might occur in some patients.
Pregnancy and Lactation:
As with other NSAIDs, the use of medicaments containing diclofenac is not recommended in late pregnancy. Minute amounts of diclofenac appear in breast milk with no adverse effects on suckling mt ants.
Drug Interactions: _________________________________
- As with other NSAIDs, diclofenac increases plasma THIS IS A MEDICAMENT
concentrations of digoxin, lithium and methotrexate. Medicament is a product which affects
- NSlDs attenuate the effects of antihypertensives and your health and its consumption contrary
diuretics to instructions is dangerous for you.
• Incidence of coagulopathy increases if NSAIDs are used Follow strictly the doctor’s prescription, the
with wart arm, method of use and the instructions of the
_________ Interference with laboratory tests: pharmacist who sold the medicament.
_________ None reported. - The doctor and the pharmacist are the
Overdosage and Treatment: experts in medicines, their benefs and
__________ Accidental ingestion of high doses of tablets may result risks.
in nausea, vomiting, drowsiness, headache, upper • Do not by yourself interrupt the period of
— abdominal pain and GI bleeding. Treatment includes treatment prescribed.
gastric emptying, activated charcoal orally, forced - Do not repeat the same prescription
diuresis and supportive measures. without consulting your doctor.
Packing - Keep all medicarnents out of reach of
A box containing 20 tablets ( 25 or 50 mg ), 3 or 6 children.
Ampoules or 5 Suppositories.
Storage: Council of Arab Health Mlnlsters
Tablets: protect from heat, humidity and light. Union of Arab Pharmacists.
Ampoules : keep at temp. not exceeding 30° C, away
from light. Made in Egypt j
Suppositories: keep in a cool and dark place.
Keep out of the reach of children. PHARCO I .._.
IARWAau rtC.A.$
Alexandria I
Each formulation contains: tablet ampoule suppository
Diclofenac sodium 25 mg or 50 mg 75 nigl3 ml 100mg
Properties:
DECLOPHEN (didofenac sodium) is a nonsteroidal drug with antirheumatic, anti-inflammatory, _________ analgesic and antipyretic properties. DECLOPHEN effectively inhibits cyclooxygenase synthetic _________ pathway of prostaglandins responsible for inflammation, pain and lever in various rheumatic and non- _________ rheumatic conditions, Clinically, DECLOPHEN relieves manifestations of inflammation in rheumatoid __________ arthritis, ankylosing spondytitis, gouty arthritis and osteoarthritis with relief of musculoskeletal pain __________ and associated fever. DECLOPHEN is also highly effective in overcoming joint inflammation, swelling
and morning stiffness with improvement of joint mobility and function. In non-rheumatic conditions, _____ DECLOPHEN exerts a potent analgesic effect relieving post-operative-and post-traumatic pain, and pain associated with sport injuries and gynecological conditions. DECLOPHEN also effectively relieves biliary and renal colic. DECLOPHEN is available in three different dosage forms (tablets, ampoules and suppositories) to cover a wide spectrum of clinical applications in acute and chronic diseases of joints, muscles and bones with excellent safety and patient compliance.
Pharmacokinetlcs:
Following administration of DECLOPHEN tablets, ampoules (IM) or suppositories, diclofenac is rapidly absorbed from the site of administration. Peak plasma concentrations are achieved within 1.5 2 hours after oral administration and much faster following (IM) injection, Diclofenac is highly distributed in body tissues and fluids, and concentrations equivalent to those in plasma are rapidly reached in the synovial fluid and persist much longer. The crug is 99% bound to plasma proteins and is metabozed in the liver. Diclofenac is excreted mainly as metabolites in urine (>60%) and in the bile (>30%) with mean plasma half-life of 1-2 hours. The drug crosses the placenta and trace amounts appear in breast milk.
Indications:
- Osteoarthritis.
- Rheumatoid arthritis. )
- Ankylosing spondylitis.
- Gouty arthritis.
- Painful shoulder resulting from peritendinitis, capsulitis, bursitis and acute arthritis.
• Non-articular rheumatism.
• Post-operative pain, sport injuries and post-traumatic painful and inflammatory conditions.
- Primary dysmenormhea and other painful gynecological conditions.
- Bihary and renal colic.
Dosage:
Tablets: 1 -2 DECLOPHEN 25 Tablets three times daily or one DECLOPHEN 50 Tablet, 2 - 3 times daily or as directed by the physician.
Ampoules (IM) : one DECLOPHEN ampoule daily or every 12 hours according to severity of the condition or as directed by the physician.
Suppositories : one DECLOPHEN suppository daily at bedtime or as directed by the physician.
Contraindications:
Hypersensitivity to cliclofenac and active peptic ulcer.
Precautions:
As with other nonsteroidal anti-inflammatory drugs (NSAIOs), DECLOPHEN should be given with care to patients receiving oral anticoagulants. Renal function must be evaluated during long-term therapy. Side Effects:
DECLOPHEN is safe and well-tolerated. Mild and infrequent GI disturbances (epigastric pain, nausea), skin rash, pruritus, malaise, headache or edema might occur in some patients.
Pregnancy and Lactation:
As with other NSAIDs, the use of medicaments containing diclofenac is not recommended in late pregnancy. Minute amounts of diclofenac appear in breast milk with no adverse effects on suckling mt ants.
Drug Interactions: _________________________________
- As with other NSAIDs, diclofenac increases plasma THIS IS A MEDICAMENT
concentrations of digoxin, lithium and methotrexate. Medicament is a product which affects
- NSlDs attenuate the effects of antihypertensives and your health and its consumption contrary
diuretics to instructions is dangerous for you.
• Incidence of coagulopathy increases if NSAIDs are used Follow strictly the doctor’s prescription, the
with wart arm, method of use and the instructions of the
_________ Interference with laboratory tests: pharmacist who sold the medicament.
_________ None reported. - The doctor and the pharmacist are the
Overdosage and Treatment: experts in medicines, their benefs and
__________ Accidental ingestion of high doses of tablets may result risks.
in nausea, vomiting, drowsiness, headache, upper • Do not by yourself interrupt the period of
— abdominal pain and GI bleeding. Treatment includes treatment prescribed.
gastric emptying, activated charcoal orally, forced - Do not repeat the same prescription
diuresis and supportive measures. without consulting your doctor.
Packing - Keep all medicarnents out of reach of
A box containing 20 tablets ( 25 or 50 mg ), 3 or 6 children.
Ampoules or 5 Suppositories.
Storage: Council of Arab Health Mlnlsters
Tablets: protect from heat, humidity and light. Union of Arab Pharmacists.
Ampoules : keep at temp. not exceeding 30° C, away
from light. Made in Egypt j
Suppositories: keep in a cool and dark place.
Keep out of the reach of children. PHARCO I .._.
IARWAau rtC.A.$
Alexandria I
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