Abilaxine tablet, adult suppository and infantile suppository

 Summary

Abilaxine is the trade name for bisacodyl, a stimulant laxative available in three formulations: enteric‑coated 5 mg tablets, 10 mg adult suppositories, and 5 mg pediatric (infantile) suppositories . Oral tablets typically produce a bowel movement within 6–12 hours, while rectal suppositories—both adult and pediatric—act faster, generally within 15–60 minutes . Adult suppositories are indicated for patients aged 10 years and older, whereas the 5 mg pediatric suppository is reserved for children 4–9 years on a physician’s advice . All formulations are intended for short‑term use (up to 1 week) to minimize the risk of dependence, electrolyte imbalance, and mucosal irritation .

Abilaxine Tablet

Composition & Formulation

The tablet formulation contains bisacodyl USP 5 mg as the sole active ingredient .

Inactive components include enteric‑coating polymers and excipients such as acacia, calcium carbonate, and polyethylene glycol .

Mechanism of Action

Bisacodyl directly stimulates the colonic mucosal nerve plexus, enhancing peristaltic contractions and increasing secretion of water and electrolytes into the intestinal lumen .

Indications

– Relief of occasional constipation and irregularity 

– Bowel preparation prior to diagnostic procedures (e.g., colonoscopy) 

Dosage & Administration

– Adults (≥ 12 years): 1–3 tablets (5–15 mg) orally once daily, preferably at bedtime; produces a bowel movement in 6–12 hours .

– Children 6–< 12 years: 1 tablet (5 mg) orally once daily; children < 6 years require medical supervision .

– Administration tips: Swallow whole with water; do not chew or crush; avoid antacids or milk within 1 hour of dosing .

Side Effects & Precautions

Common adverse effects include abdominal cramps, faintness, and electrolyte disturbances with prolonged use . Contraindications encompass intestinal obstruction, acute abdominal pain, and known hypersensitivity to bisacodyl .

Storage

Store at 15–30 °C, protecting from excessive humidity; keep out of reach of children .

Adult Suppository

Composition & Formulation

Each suppository contains bisacodyl USP 10 mg as the active ingredient .

Inactive base: hydrogenated vegetable oil .

Mechanism of Action

Acts locally by stimulating colonic mucosal nerve endings to elicit peristalsis and fluid secretion .

Indications

Temporary relief of occasional constipation and irregularity .

Dosage & Administration

– Adults & children ≥ 10 years: 1 suppository (10 mg) rectally once daily, producing a bowel movement in 15–60 minutes .

– Procedure: Remove foil wrap, insert the pointed end gently into the rectum while lying on the side, and remain recumbent for a few minutes to ensure retention .

Side Effects & Precautions

May cause rectal burning, mild cramps, abdominal discomfort, or faintness; not recommended for children < 6 years without medical advice . Contraindicated in the presence of rectal bleeding, proctitis, or undiagnosed abdominal pain .

Storage

Store at room temperature (15–30 °C) away from heat and moisture; keep foil-sealed until use .

Infantile (Pediatric) Suppository

Composition & Formulation

The pediatric suppository contains bisacodyl USP 5 mg, formulated in a glycerin or hydrogenated vegetable oil base .

Indications

Short‑term relief of occasional constipation in children aged 4–9 years, under medical supervision .

Dosage & Administration

– Children 4–9 years: 1 suppository (5 mg) rectally once daily, with an onset of 15–60 minutes .

– Procedure: Wash hands, unwrap, and gently insert the pointed end into the rectum; have the child lie still for a few minutes .

Side Effects & Precautions

Possible rectal irritation, mild cramps, or electrolyte imbalance if overused; not for routine use beyond one week . Contraindicated in infants under 4 years without specific physician direction .

Storage

Store at room

 temperature (15–30 °C), protected from moisture; keep out of children’s reach .