1. Disclaimer
The information provided in this report is intended for educational and professional reference purposes only and does not replace medical advice, diagnosis, or treatment. Clinical decisions should always be based on official prescribing information approved by local regulatory authorities and the judgment of qualified healthcare professionals.
We do not guarantee the accuracy, currency or completeness of information regarding medications or medical products, and official sources should be verified before making any decisions. By using this blog, you agree to assume personal responsibility for relying on the information provided.
2. Summary
All-Vent Syrup is a combination cough preparation formulated for the management of productive cough associated with bronchospasm. It combines a β2-agonist bronchodilator, a mucolytic, an expectorant, and a soothing agent to facilitate airway dilation, mucus liquefaction, and expectoration. The product is marketed as sugar-free and dye-free, which may be beneficial for certain patient populations.
3. Brand Name
All-Vent® Syrup
4. Category
Bronchodilator – Mucolytic – Expectorant – Demulcent (Combination Cough & Respiratory Preparation)
5. Active Ingredient
Each 5 mL of syrup contains:
- Terbutaline Sulphate — 1.25 mg
- Bromhexine Hydrochloride — 4 mg
- Guaifenesin — 50 mg
- Menthol — 2.5 mg
6. Pharmaceutical Form & Strength
Oral syrup, multidose bottle
Strengths as listed per 5 mL
7. Manufacturer & Marketing Authorization Holder
BORG Pharmaceutical Industries
Publicly accessible regulatory details regarding the marketing authorization holder and approval status in different countries are limited. Official local product registration documents should be consulted.
8. Mechanism of Action
- Terbutaline Sulphate: A selective β2-adrenergic agonist that relaxes bronchial smooth muscle, leading to bronchodilation and relief of bronchospasm.
- Bromhexine HCl: Enhances lysosomal activity and reduces mucus viscosity by depolymerizing mucopolysaccharide fibers.
- Guaifenesin: Increases respiratory tract fluid secretion, reducing mucus adhesiveness and facilitating expectoration.
- Menthol: Produces a local cooling sensation and mild antitussive effect through sensory nerve stimulation.
9. Spectrum of Activity
Not applicable.
(This product does not possess antimicrobial activity.)
10. Pharmacokinetics
- Terbutaline: Well absorbed orally; undergoes hepatic metabolism; excreted mainly via urine.
- Bromhexine: Rapid oral absorption; extensive first-pass metabolism; active metabolites contribute to effect.
- Guaifenesin: Rapidly absorbed and metabolized; short plasma half-life.
- Menthol: Absorbed and metabolized hepatically.
Precise pharmacokinetic parameters for the fixed-dose combination are not available.
11. Indications
Symptomatic treatment of productive cough associated with bronchospasm, including:
- Acute and chronic bronchitis
- Bronchial asthma (as adjunctive therapy)
- Chronic obstructive pulmonary disease (COPD)
- Bronchiectasis and emphysema
12. Administration
Oral use only.
Should be taken after meals unless otherwise directed by a healthcare professional.
13. Method of Preparation
Not applicable.
(The product is supplied as a ready-to-use oral syrup.)
14. Contraindications
- Hypersensitivity to any component of the formulation
- Known hypersensitivity to sympathomimetic amines
15. Warnings & Precautions
- Use with caution in patients with cardiovascular disease, arrhythmias, or hypertension
- Caution in hyperthyroidism, diabetes mellitus, or seizure disorders
- β2-agonists may cause hypokalemia, especially when combined with diuretics
- Use cautiously in patients with a history of peptic ulcer disease
- Not intended as monotherapy for acute severe asthma attacks
16. Drug Interactions
- Non-selective beta-blockers: May antagonize bronchodilator effect and provoke bronchospasm
- Diuretics / Corticosteroids: Increased risk of hypokalemia
- MAO inhibitors & tricyclic antidepressants: May potentiate cardiovascular effects of terbutaline
17. Side Effects
Common:
- Tremor, nervousness, palpitations, headache
Gastrointestinal:
- Nausea, mild gastric discomfort
Others:
- Dizziness, sweating, muscle cramps
Side effects are generally dose-related and reversible.
18. Use in Special Populations
- Pregnancy: Use only if benefit outweighs risk; safety of combination not fully established
- Lactation: Caution advised; limited data available
- Pediatrics: Dosage should follow medical advice
- Elderly: Increased sensitivity to β-agonist effects possible
19. Storage Conditions
- Store below 25°C, protected from light and moisture.
- Keep out of reach of children.
20. Additional Sections
Regulatory Status:
Publicly available regulatory approval data are limited. Verification with national drug regulatory authorities is recommended.
21. Frequently Asked Questions (FAQ)
Q: Is All-Vent suitable for dry cough?
A: No. It is intended for productive cough with mucus and bronchospasm.
Q: Can diabetic patients use All-Vent?
A: The product is marketed as sugar-free; however, diabetic patients should still consult their physician.
Q: Does All-Vent replace asthma controller therapy?
A: No. It is for symptomatic relief and does not replace inhaled corticosteroids or long-term asthma control medications.
22. References
- DrugBank Online – Bromhexine Hydrochloride
- DrugBank Online – Terbutaline
- Drugs.com – Guaifenesin Monograph
- British National Formulary (BNF) – Individual Active Ingredients