TORSERETIC TORSERETIC - torsemide 5mg-10mg -20mg Tablet TORSERETIC - torsemide 20mg/2m1 Injection DESCRIPTION TORSERETIC (torsemide) is a diuretic of the pyridine-sulfonylurea class. Inactive Ingredient of tablet: lactose monohydrate Microcrystalline cellulose -povidone -Magnesium stearate - Croscarmellose. Inactive Ingredient of ampoule: Polyethylene glycol 400- Tromethamine- Sodium Hydroxide- Water for injection. CLINICAL PHARMACOLOGY Mechanism of Action - Micropuncture studies have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2C1—carrier system. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. - Diuretic activity thus correlates better with the rate of drug excretion in the urine than with the concentration in the blood. - Torsemide increases the urinary excretion of sodium, chloride, and wa...
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